Thioridazine hydrochloride suppliers

Thioridazine hydrochloride

CAS:: 130-61-0

MF:: C21H27ClN2S2

MW:: 407.04

SecurityInformation

Symbol(GHS) ：: GHS07

Signal word ：: Warning

Hazard statements ：: H302

Precautionary statements ：: P264-P270-P301+P312-P501

Hazard Codes ：: Xn,N

Risk Statements ：: 22-36/37/38-50/53

Safety Statements ：: 26-36-60-61

RIDADR ：: UN 3077 9/PG 3

WGK Germany ：: 3

RTECS ：: SP2275000

HazardClass ：: 9

HS Code ：: 2934302300

Use：: Thioridazine hydrochloride,10-[2-(1-methyl-2-piperidyl)ethyl]-2-(methylthio)phenothiazine monohydrochloride (Mellaril), is amember of the piperidine subgroup of the phenothiazines.The drug has a relatively low tendency to produce EPS. Thedrug has high anticholinergic activity, and this activity in thestriatum, counterbalancing a striatal DA block, may be responsiblefor the low EPS. It also has been suggested thatthere may be increased DA receptor selectivity, which may be responsible. The drug has sedative and hypotensive activityin common with chlorpromazine and less antiemeticactivity. At high doses, pigmentary retinopathy has been observed.Its major metabolites include N-demethylated, ringhydroxylated,and S-oxidized products. Thioridazine isprominently converted to the active metabolite mesoridazine(discussed next), which probably contributes to the antipsychoticactivity of thioridazine.

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