Tetracaine suppliers

Tetracaine

CAS:: 94-24-6

MF:: C15H24N2O2

MW:: 264.36

SecurityInformation

Symbol(GHS) ：: GHS06,GHS08

Signal word ：: Danger

Hazard statements ：: H301-H317-H351

Precautionary statements ：: P280-P301+P330+P331+P310

Hazard Codes ：: Xn,Xi

Risk Statements ：: 22-40-42/43-43

Safety Statements ：: 22-36/37

RIDADR ：: UN 2811

WGK Germany ：: 3

RTECS ：: DG4725000

HazardClass ：: 6.1

PackingGroup ：: III

HS Code ：: 29224999

Use：: Tetracaine was developed to address the low potency andshort duration of action of procaine and chloroprocaine. The addition of the butyl side chain on the para nitrogen increasesthe lipid solubility of the drug and enhances the topical potencyof tetracaine. The plasma half-life is 120 to 150 seconds.Topically applied tetracaine to unbroken skin requires 30 to 45minutes to confer topical anesthesia. Tetracaine 4% gel is superiorthan eutectic mixture with lidocaine (EMLA) (an emulsionof lidocaine and prilocaine) in preventing pain associatedwith needle procedures in children. Tetracaine metabolism issimilar to procaine ester metabolism yielding parabutylaminobenzoicacid and dimethylaminoethanol and conjugatesexcreted in the urine. The pKa of the dimethylated nitrogen is8.4 and tetracaine is formulated as a hydrochloride salt with apH of 3.5 to 6.0. The increased absorption from topical siteshas resulted in reported toxicity. Overdoses of tetracaine mayproduce central nervous system (CNS) toxicity and seizure activitywith fatalities from circulatory depression reported.No selective cardiac toxicity is seen with tetracaine althoughhypotension has been reported. Tetracaine is employed for infiltrationanesthesia, spinal anesthesia, or topical use.

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Wuhan Haorong Biotechnology Co.,ltd