Telaprevir suppliers

Telaprevir

CAS:: 402957-28-2

MF:: C36H53N7O6

MW:: 679.85

SecurityInformation

Symbol(GHS) ：: GHS08

Signal word ：: Warning

Hazard statements ：: H361fd

Precautionary statements ：: P201-P202-P280-P308+P313-P405-P501

Safety Statements ：: 24/25

WGK Germany ：: WGK 3

HS Code ：: 29339900

Storage Class：: 13 - Non Combustible Solids

Hazard Classifications：: Repr. 2

Hazardous Substances Data：: 402957-28-2(Hazardous Substances Data)

Use：: The hepatitis C virus (HCV) protease inhibitor telaprevir (VX-950, MP- 424,LY-570310) was approved by the U.S. FDA in May 2011 for the treatment of genotype 1 chronic HCV infection in adult patients in combination with peginterferon alfa and ribavirin (PR). Telaprevir and boceprevir (vide supra) are the first two HCV protease inhibitors to be approved for treatment of HCV infection. Telaprevir is a HCV NS3-4A protease inhibitor that exerts its antiviral effect by blocking the release of nonstructural viral proteins from a polyprotein precursor. Telaprevir is a potent inhibitor of the protease (IC50=10 nM) and is active in cell culture (HCV 1b replicon assay, EC50=354 nM). Telaprevir was identified from efforts to truncate a decamer peptide inhibitor derived from the natural substrate NS5A-5B and was guided by structure-based design. The ketoamide group of telaprevir forms a covalent, reversible bond with the active site serine hydroxyl of the protease and compensates for the loss of affinity resulting from truncation of the peptide. Despite the presence of the reactive keto-amide group, telaprevir is 500-fold less potent against other serine proteases. Synthesis of the key octahydrocyclopenta[c]pyrrole-1-carboxylic acid fragment of telaprevir is achieved by a-deprotonation of Boc-protected 3-azabicyclo[3.3.0]nonane followed by reaction with CO2 and resolution of the racemic acid. Alternatively, deprotonation is carried out in the presence of a chiral amine to give the enantiomerically enriched acid.Telaprevir is a peptidomimetic inhibitor of hepatitis C virus protease. Labeled Telaprevir, intended for use as an internal standard for the quantification of Telaprevir by GC- or LC-mass spectrometry.Telaprevir is White Solid

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You can find Telaprevir suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Capot Chemical Co.,Ltd.

VX-950(Telaprevir)
Remarks: Purity: 98%(Min,HPLC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
TEL: +86-（0）57185586718
CHINA Trader

Henan Tianfu Chemical Co.,Ltd.

TIANFU CHEM---Cyclopenta(c)pyrrole-1-carboxamide, (2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydro-, (1S,3aR,6aS)-
Remarks: Purity: 99% | Package: 25KG;5KG;1KG
TEL: 0371-+86-0371-55170693
CHINA Trader

career henan chemical co

Telaprevir intermediates
Remarks: Purity: 98% | Package: 1KG;10USD
TEL: 0371-86658258
CHINA Reagent

$10.00

Lotusland Life Sciences

Telaprevir
Remarks: Purity: .99 | Package: 5KG;1KG/aluminum foil package; 25kg/drum | CustNote: Paypal,credit card,western union,bank transfer
CHINA Trader