StaupriMide suppliers

StaupriMide

CAS:: 154589-96-5

MF:: C35H28N4O5

MW:: 584.62

Use：: Stauprimide is an enhancer stem cell differentiation into endoderm. In vitro differentiation of embryonic stem cells is of great interest to regenerative medicine, and current protocols are labor-intensive and expensive. Small molecules that induce or enhance differentiation are highly desired. High-content screening identified compounds that enhance endodermal differentiation in the presence of low levels of Activin A. Stauprimide increased definitive endodermal markers but not markers for visceral/parietal endoderm or mesoderm. Stauprimide-differentiated cells could be further differentiated into hepatocytes. Stauprimide treatment during differentiation decreased the concentration of Activin A required for definitive endoderm formation, and it eliminated the need for serum. The mechanism of action of stauprimide is to sensitize cells for differentiation. Stauprimide enabled differentiation into other cell lineages under varying differentiation conditions, including neurons, hematopoietic mesoderm, beating cardiac myocytes, and skeletal muscle. Stauprimide is a semi-synthetic analogue of the staurosporine family of indolocarbazoles. Stauprimide was first published in 1994 as part of an extensive structure-activity investigation to improve the selective inhibition of protein kinase C as potential antitumour agents. Stauprimide increases the efficiency of the directed differentiation of mouse and human embryonic stem cells in synergy with defined extracellular signalling cues. Stauprimide interacts with NME2 (PUF) transcription factor to down-regulate c-Myc expression, leading to differentiation of stem cells. Labelled Stauprimide (S684700). It is an enhancer stem cell differentiation into endoderm. Stauprimide is a semi-synthetic analogue of the staurosporine family of indolocarbazoles. Stauprimide was first published in 1994 as part of an extensive structure-activity investigation to improve the selective inhibition of protein kinase C as potential antitumor agents. Stauprimide increases the efficiency of the directed differentiation of mouse and human embryonic stem cells in synergy with defined extracellular signalling cues. Stauprimide interacts with NME2 (PUF) transcription factor to down-regulate c-Myc expression, leading to differentiation of stem cells.

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You can find StaupriMide suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

TargetMol Chemicals Inc.

Stauprimide
Remarks: Package: 5mg;708USD|1mg;289USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
TEL: +1-781-999-5354
UNITED STATES Trader

$987.00

$419.00

Career Henan Chemica Co

StaupriMide
Remarks: Purity: 95% | Package: 1g;17.0USD
TEL: 0371-86658258
CHINA Trader

Aladdin Scientific

Stauprimide
Remarks: Purity: 99% | Package: $216.9/1mg;$692.9/5mg;Bulk package | CustNote: 99%
TEL: 552-7181
UNITED STATES Trader

QUALITY CONTROL SOLUTIONS LTD.

StaupriMide
Remarks: Purity: 95% HPLC | Package: 10MG;25MG;50MG;100MG
TEL: +86-0755-66853366
CHINA Trader

Apollo Scientific Ltd.

Stauprimide
Remarks: Brand: Apollo Scientific | Product Number: BIS6400
TEL: 44 161 406 0505
UNITED KINGDOM Trader

$89.00/1mg

$356.00/5mg

Tocris Bioscience

[9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide
Remarks: Brand: Tocris Bioscience | Product Number: 3741 | Purity: ≥98% (HPLC)
TEL: +44 (0) 117 916 3333
UNITED KINGDOM Trader

$255.00/100 ug

DC Chemicals

Stauprimide
Remarks: Brand：dcchemicals | Product Number：DC26088 | Purity：>98%
TEL: +86-21-58447131
UNITED STATES Trader

ChemScene LLC

Stauprimide
Remarks: Brand:ChemScene | Product Number:CS-3530 | Purity:99.0%
TEL: 610-426-3128
UNITED STATES Trader

$238.00/1mg

$758.00/5mg

Glentham Life Sciences

Stauprimide
Remarks: Brand：glenthamls | Product Number：GP1449
TEL: +44 (2033) 978-798
UNITED KINGDOM Trader

Sigma-Aldrich Chemicals Private Limited

Stauprimide
Remarks: Brand:sigma aldrich | Product Number:S2951 | Purity:≥98%(HPLC)
TEL: 1-800-309-6000
INDIA Trader

$22277.80/1MG

$86632.50/5MG