Roflumilast suppliers

Roflumilast

CAS:: 162401-32-3

MF:: C17H14Cl2F2N2O3

MW:: 403.21

SecurityInformation

Symbol(GHS) ：: GHS07

Signal word ：: Warning

Hazard statements ：: H315-H319-H335

Precautionary statements ：: P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes ：: Xi

Risk Statements ：: 36/37/38

Safety Statements ：: 26

WGK Germany ：: 3

RTECS ：: CV3325600

HS Code ：: 2933.39.4100

Use：: Roflumilast is taken orally and is metabolized by cytochrome oxidase P45(CYP)3A4 and CYP1A2 enzyme into N-oxide. Roflumilast N-oxides activity is only 2-3 times weaker than that of roflumilast, and it also has relatively high PDE-4 selectivity. 90% of PDE-4 inhibition in the body is achieved by roflumilast N-oxide, while the other 10% is achieved by the original drug. A daily 500ng oral dose of roflumilast for a healthy person will produce a free blood concentration of roflumilast N-oxide in 24 hours of about 1-2 nmolL-1, and its serum protein binding rate is about 97%. Smoking has little impact on roflumilasts pharmacokinetics. Roflumilast mostly affects inflammation cells related to asthma, including eosinophils, neutrophils, and mast cells. This drug can specifically affect a certain enzyme that participates in smooth muscle contraction, it can prevent cAMP decomposition, thus preventing the signal transduction for inflammatory reactions, and it is anti-inflammatory, giving it relatively good curative effects in clinically treating asthma and COPD. Roflumilast can also significantly extend the deterioration of respiratory symptoms while also dramatically increasing patients quality of life.

More▼

You can find Roflumilast suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Hefei TianRui Pharmaceutical Chemical Co., Ltd.

Roflumilast
Remarks: Purity: NLT 99％ HPLC; USP, DMF PREPARING | Package: 20Kg/Drum|10Kg/Drum|5Kg/Drum
TEL: 0551-055168665055
CHINA Manufacturer

Hebei Weibang Biotechnology Co., Ltd

Roflumilast
Remarks: Purity: 99.5%|Package: 1ASSAYS;25.00;USD
CHINA Trader

￥25.00/1ASSAYS

Hebei Mojin Biotechnology Co., Ltd

Roflumilast
Remarks: Purity: 99% | Package: 25KG
TEL: +86 13288715578
CHINA Service provider

￥0.00/25KG

Hebei Chuanghai Biotechnology Co,.LTD

Roflumilast
Remarks: Purity: 99%|Package: 1KG;10.00;USD
CHINA Trader

￥10.00/1KG

Anhui Ruihan Technology Co., Ltd

Roflumilast
Remarks: Purity: 99% | Package: 1kg;50USD
CHINA Trader

￥50.00/1kg

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Roflumilast
Remarks: Purity: More Than 99% | Package: 1g
TEL: 010-87925929
CHINA Trader

￥0.00/1g

Chengdu D-innovation Pharmaceutical Co.，LTD

RofluMilast; 3-(cyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-BenzaMide
Remarks: Purity: NLT 99.5% | Package: 10g;50g;100g;500g;1kg;10kg;25kg
TEL: 028-85105512
CHINA Manufacturer

Henan Tianfu Chemical Co.,Ltd.

Roflumilast Treatment for chronic obstructive pulmonary disease(COPD)
Remarks: Purity: 99% | Package: 25KG;5KG;1KG
TEL: 0371-+86-0371-55170693
CHINA Trader

Hangzhou FandaChem Co.,Ltd.

Roflumilast
Remarks: Purity: as in COA | Package: as customers' requirements
CHINA Trader

ATK CHEMICAL COMPANY LIMITED

Roflumilast
Remarks: Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
TEL: 21-51877795
CHINA Reagent