Peramivir suppliers

Peramivir

CAS:: 330600-85-6

MF:: C15H28N4O4

MW:: 328.41

Use：: Peramivir is a neuraminidase (NA) inhibitor that was approved in Japan in 2010 for treatment of patients with influenza. It is the only NA inhibitor available for IV use and is the first of two NA inhibitors approved in 2010, the second being the inhaled drug laninamivir octanoate . Peramivir is the only NA inhibitor approved for IV use,which gives it a unique place in influenza treatment for seriously ill patients. Peramivir was discovered using structure-based drug design and is synthesized in six steps from Boc-protected methyl (1S,4R)-4-amino-cyclopent-2-enecarboxylate, which is prepared from 2-azabicyclo[2.2.1]hept-5-en-3-one. Cycloaddition of the cyclopentene olefin with a nitrile oxide provided an intermediate fused cyclopentane-dihydroisoxazole. Hydrogenolysis and acetylation set up a fully functionalized cyclopentane with all four stereocenters established. Deprotection of the amine and acid groups was followed by installation of the guanidine moiety to provide peramivir. Like zanamivir and oseltamivir, peramivir is a potent inhibitor of influenza virus A and B NA [strain A(H1N1) IC50= 0.34 nM; strain A(H3N2) IC50= 0.60 nM; strain B IC50= 1.36 nM]. However, peramivir is less potent against oseltamivirresistant viruses that have the H275Y NA mutation. These viruses remain sensitive to zanamivir. Peramivir is active against influenza A and B viruses and has a lowenzymatic off-rate, suggesting that it could inhibitNAactivity for a prolonged period and allow lower frequency of dosing. Peramivir has proven efficacious in preclinical animal models of influenza infection.Peramivir is anew antiviral agent for influenza treatment; it can be used as neuraminidase inhibitor for treating human and avian influenza Peramivir isamember of the class of guanidines that is used (as its trihydrate) for the treatment of acute uncomplicated influenza in patients 18 years and older who have been symptomatic for no more than two days.

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You can find Peramivir suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Shanghai Daken Advanced Materials Co.,Ltd

(1S,2R,3R,4R)-3-(1-acetamido-2-ethyl-butyl)-4-(diaminomethylideneamino)-2-hydroxy-cyclopentane-1-carboxylic acid
Remarks: Purity: 99% | Package: 100g ;1KG ;5KG 25KG
TEL: 371-+86-371-66670886
CHINA Trader

Henan Tianfu Chemical Co.,Ltd.

(1S,2R,3R,4R)-3-(1-acetamido-2-ethyl-butyl)-4-(diaminomethyl 330600-85-6
Remarks: Purity: 99% | Package: 25KG;5KG;1KG
TEL: 0371-+86-0371-55170693
CHINA Trader

career henan chemical co

(1S,2R,3R,4R)-3-(1-acetamido-2-ethyl-butyl)-4-(diaminomethylideneamino)-2-hydroxy-cyclopentane-1-carboxylic acid
Remarks: Purity: 95%-99% | Package: 1kg;1USD
TEL: 0371-86658258
CHINA Reagent

￥1.00/1kg

CONIER CHEM AND PHARMA LIMITED

(229614-55-5) peramivir
Remarks: Purity: 0.99 | Package: 1kg
CHINA Trader

TargetMol Chemicals Inc.

Peramivir；RWJ 270201;BCX1812;RWJ270201;BCX 1812
Remarks: Purity: 99.82% | Package: 1mg;30USD|5mg;64USD|10mg;106USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
TEL: +1-781-999-5354
UNITED STATES Trader

Finetech Industry Limited

(1S,2R,3R,4R)-3-(1-acetamido-2-ethyl-butyl)-4-(diaminomethylideneamino)-2-hydroxy-cyclopentane-1-carboxylic acid
Remarks: Purity: 98% | Package: 1g,10g,25g,100g,500g,1kg
TEL: +86-27-87465837
CHINA Trader

XI'AN TIANGUANGYUAN BIOTECH CO., LTD.

Peramivir
Remarks: Purity: 99% | Package: 100G; 1KG; 5KG; 25KG | CustNote: Pharmaceutical grade
TEL: +86-029-86333380
CHINA Trader

Zhejiang J&C Biological Technology Co.,Limited

Peramivir
Remarks: Purity: 99% | Package: 5KG;1KG | CustNote: Peramivir
TEL: 1-2135480471
CHINA Trader

Hefei TNJ Chemical Industry Co.,Ltd.

3(R)-[1(S)-Acetamido-2-ethylbutyl]-4(R)-guanidino-2(S)-hydro...
TEL: 0551-65418684
CHINA Manufacturer

Hebei Fengjia New Material Co., Ltd

Peramivir
Remarks: Purity: 0.99 | Package: 5KG;1KG
TEL: +86-0311-87836622
CHINA Trader