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ChemicalBook >> CAS DataBase List >>Papaverine hydrochloride

Papaverine hydrochloride suppliers

Papaverine hydrochloride

CAS:: 61-25-6

MF:: C20H22ClNO4

MW:: 375.85

SecurityInformation

Symbol(GHS) ：: GHS06

Signal word ：: Danger

Hazard statements ：: H301

Precautionary statements ：: P264-P270-P301+P310-P405-P501

Hazard Codes ：: Xn,C,F

Risk Statements ：: 22-34-11

Safety Statements ：: 22-45-36/37/39-26-16

RIDADR ：: UN 1544 6.1/PG 3

WGK Germany ：: 1

RTECS ：: NW8575000

F ：: 8

TSCA ：: Yes

HazardClass ：: 6.1

PackingGroup ：: III

HS Code ：: 29391900

Toxicity：: LD50 in mice, rats (mg/kg): 27.5, 20 i.v.; 150, 370 s.c. (Levis)

Use：: Papaverine hydrochloride,6,7-dimethoxy-1-veratrylisoquinoline hydrochloride,was isolated by Merck in 1848 from opium,in which it occurs to the extent of about 1%. Althoughits natural origin is closely related to morphine, the pharmacologicalactions of papaverine hydrochloride areunlike those of morphine. Its main effect is as a spasmolyticon smooth muscle, acting as a direct, nonspecificrelaxant on vascular, cardiac, and other smooth muscle.Because of its broad antispasmodic action on ACh muscarinicreceptors, it is often called a nonspecific antagonist.Papaverine hydrochloride has been used in the treatmentof peripheral vascular disorders, but its use is limitedby lack of potency. Papaverine hydrochloride interferes with the mechanismof muscle contraction by inhibiting the cyclic nucleotidephosphodiesterases in smooth muscle cells responsible forconverting cAMP and cyclic guanosine monophosphate(cGMP) to 5' -AMP and 5' -GMP, respectively. The increasedlevels of cAMP and cGMP are associated with muscle relaxation through their phosphorylation of myosinlight-chain kinase.PAPAVERINE HYDROCHLORIDE is Crystalline Solid Papaverine hydrochloride,6,7-dimethoxy-1-veratrylisoquinoline hydrochloride,was isolated by Merck in 1848 from opium,in which it occurs to the extent of about 1%. Althoughits natural origin is closely related to morphine, the pharmacologicalactions of papaverine hydrochloride areunlike those of morphine. Its main effect is as a spasmolyticon smooth muscle, acting as a direct, nonspecificrelaxant on vascular, cardiac, and other smooth muscle.Because of its broad antispasmodic action on ACh muscarinicreceptors, it is often called a nonspecific antagonist.Papaverine hydrochloride has been used in the treatmentof peripheral vascular disorders, but its use is limitedby lack of potency. Papaverine hydrochloride interferes with the mechanismof muscle contraction by inhibiting the cyclic nucleotidephosphodiesterases in smooth muscle cells responsible forconverting cAMP and cyclic guanosine monophosphate(cGMP) to 5' -AMP and 5' -GMP, respectively. The increasedlevels of cAMP and cGMP are associated with muscle relaxation through their phosphorylation of myosinlight-chain kinase.

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You can find Papaverine hydrochloride suppliers, manufacturers, and distributors from countries such as CHINA, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

CONIER CHEM AND PHARMA LIMITED

papaverine hydrochloride
Remarks: Purity: 99% | Package: 1kg
CHINA Trader

Hubei Ipure Biology Co., Ltd

Papaverine Hydrochloride
Remarks: Purity: 99% | Package: 10g;500g;1kg;10kg
CHINA Trader

Shaanxi Dideu Medichem Co. Ltd

Papaverine hydrochloride USP/EP/BP
Remarks: Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
TEL: +86-029-89586680
CHINA Trader

LEAP CHEM CO., LTD.

Papaverine hydrochloride
Remarks: Package: 1g; 5g; 25g; 1kg; 5kg; 25kg
TEL: 852-30606658
CHINA Trader

Protheragen-ING

Papaverine HCl
Remarks: Package: 25g; 50g; 250g;100g; 500g; 1kg; 5kg; 10kg; 25kg
UNITED STATES Trader

Henan Fengda Chemical Co., Ltd

PapaverineHydrochloride
Remarks: Purity: 99% | Package: 1KG;25kg;200kg;1000kg Jessica | CustNote: g-kg-tons,free sample is available.Bottle/drum/IBC.Advantage products,new batches,regular stock, ready for shipment.
TEL: +86-371-86557731
CHINA Trader

Aladdin Scientific

Papaverine hydrochloride
Remarks: Purity: >=95% | Package: $9.9/250mg;$15.9/1g;$38.9/5g;Bulk package | CustNote: 95%
TEL: 552-7181
UNITED STATES Trader

Shaanxi Xianhe Biotech Co., Ltd

Papaverine hydrochloride
Remarks: Purity: 0.99 | Package: 25KG;1KG
CHINA Trader

SHANGHAI KEAN TECHNOLOGY CO., LTD.

BENZENE, 2-BROMO-1-IODO-3-METHYL-
Remarks: Purity: 0.99 | Package: 100g;1kg;5KG;1KG
TEL: +86-13817748580
CHINA Trader

Amadis Chemical Company Limited

1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinolin-2-ium chloride
Remarks: Purity: 0.97 | Package: mgs,gs,kgs | CustNote: A833127
TEL: 571-89925085
CHINA Reagent