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ChemicalBook >> CAS DataBase List >>Paliperidone

Paliperidone suppliers

Paliperidone

CAS:: 144598-75-4

MF:: C23H27FN4O3

MW:: 426.48

SecurityInformation

Symbol(GHS) ：: GHS06

Signal word ：: Danger

Hazard statements ：: H301

Precautionary statements ：: P301+P310

Hazard Codes ：: T,F

Risk Statements ：: 25-39/23/24/25-23/24/25-11

Safety Statements ：: 45-36/37-16

RIDADR ：: UN 2811 6.1/PG 3

WGK Germany ：: 3

RTECS ：: UV1164720

HazardClass ：: 6.1

PackingGroup ：: III

HS Code ：: 29349990

Hazardous Substances Data：: 144598-75-4(Hazardous Substances Data)

Toxicity：: rat,LD50,oral,65mg/kg (65mg/kg),Drug Development Research. Vol. 33, Pg. 399, 1994.

Use：: Paliperidone, (±)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one(Invega), is essentially insoluble in water and is available asextended-release tablets. Paliperidone is delivered at a constantrate using an osmotic drug release device (OsmoticRelease Oral Systems [OROS]). The absolute bioavailabilityof paliperidone is 28%, and studies in healthy subjects on ahigh-fat, high-calorie meal showed an increase in AUC.Paliperidone is 74% bound to plasma proteins. After a single,1-mg dose of C-paliperidone, 59% of the dose was excretedin the urine as unchanged drug, and 32% of the dose was recoveredas metabolites. Most of the drug (80%) is excreted bythe kidneys. Paliperidone is metabolized by dealkylation, hydroxylation,dehydrogenation, and scission of the benzoxazolering. None of these metabolic pathways account for morethan 10% of the dose. The terminal elimination half-life ofpaliperidone is 23 hours.

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You can find Paliperidone suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Shandong Risen-Sun Pharmaceutical Co., Ltd