methoxyflurane suppliers

methoxyflurane

CAS:: 76-38-0

MF:: C3H4Cl2F2O

MW:: 164.97

SecurityInformation

Symbol(GHS) ：: GHS02,GHS07

Signal word ：: Warning

Hazard statements ：: H226-H319-H341

Precautionary statements ：: P210-P241-P308+P311

Hazard Codes ：: Xi

Risk Statements ：: 10

Safety Statements ：: 23-24/25

RIDADR ：: 3271

OEL：: Ceiling: 2 ppm (13.5 mg/m3) [60-minute] [*Note: REL for exposure to waste anesthetic gas.]

RTECS ：: KN7820000

Hazard Note ：: Irritant

HazardClass ：: 3

PackingGroup ：: III

HS Code ：: 2909191800

Hazardous Substances Data：: 76-38-0(Hazardous Substances Data)

Toxicity：: One of the most potent of the inhalational anesthetics, having a very high blood-gas partition coefficient and low vapor pressure at room temperature. Methoxyflurane is metabolized to a great extent (about 50-70%) in the liver and, as a consequence, there may be release of high concentrations of fluoride, sufficient to exceed the threshold for renal damage. Its use for sustained anesthesia is limited because of this renal toxicity and was discontinued around 1980.

Use：: Methoxyflurane is a volatile liquid (bp＝105°C) with a highblood:gas partition coefficient and thus a slow induction andprolonged recovery. Approximately 75% of the drug undergoesmetabolism yielding dichloroacetate, difluoromethoxyacetate,oxalate, and fluoride ions. The intrarenal inorganicfluoride concentration, as a result of renal defluorination, maybe responsible for the nephrotoxicity seen with methoxyflurane.Both the concentration of F- generated and the durationfor which it remained elevated were factors in the developmentof methoxyflurane nephrotoxicity. Methoxyfluranewas removed from the U.S. market in 2000 because of saferalternatives. Both isoflurane and enflurane produce less fluorideion upon metabolism than methoxyflurane.

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