macitentan suppliers

macitentan

CAS:: 441798-33-0

MF:: C19H20Br2N6O4S

MW:: 588.27

Use：: Macitentan (also known as ACT-064992) received US FDA approval in October 2013 for the treatment of pulmonary arterial hypertension (PAH) (WHO group I) to delay disease progression. Treatment options include phosphodiesterase type 5 inhibitors, prostacyclins, and the endothelin receptor antagonists bosentan and ambrisentan. Macitentan was discovered through SAR studies starting with the bosentan structure with three main goals: (1) to increase potency for both endothelin receptor A and B (ETA and ETB) subtypes; (2) to improve tissue distribution to reach the target receptors; and (3) to avoid bile salt transport inhibition. Starting with the bosentan sulfonamido-pyrimidinyl central core, potency was increased 10-fold via incorporation of a bromopyrimidinyl ethylene glycol ether, as found in the clinical endothelin antagonist, T-0201. An aryl ether in bosentan was replaced with the bromophenyl group in macitentan, and a substituent on the 2-position of the central pyrimidine was replaced with hydrogen. Several sulfonamides and alkyl sulfamates were explored, with the propylsulfamate providing the best combination of in vitro potency, especially for ETB antagonism, and in vivo efficacy.

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You can find macitentan suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Seasons Biotechnology Co., Ltd.

Macitentan
Remarks: Purity: 99%HPLC | Package: Gram to Kilogram Class
CHINA Trader

Hefei TianRui Pharmaceutical Chemical Co., Ltd.

macitentan
Remarks: Purity: NLT 99％ HPLC; USP42|Package: 20Kg/Drum|10Kg/Drum|5Kg/Drum
TEL: 0551-055168665055
CHINA Manufacturer

Hebei Mojin Biotechnology Co., Ltd

macitentan
Remarks: Purity: 99% | Package: 25KG
CHINA Service provider

￥0.00/25KG

Hebei Guanlang Biotechnology Co,.LTD

Macitentan
Remarks: Purity: 98%|Package: 1KG;10.00;USD
TEL: +86-19930503253
CHINA Trader

￥10.00/1KG

Hebei Ganmiao New material Technology Co., LTD

macitentan
Remarks: Purity: 99.9% | Package: 1kg;10USD|10kg;9USD|100kg;7USD
TEL: 17332992504
CHINA Trader

￥10.00/1kg

￥9.00/10kg

￥7.00/100kg

Capot Chemical Co.,Ltd.

Macitentan
Remarks: Purity: 98%(Min,HPLC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
TEL: 571-571-85586718
CHINA Trader

Henan Tianfu Chemical Co.,Ltd.

macitentan
Remarks: Purity: 99% | Package: 25KG;5KG;1KG
TEL: 0371-55170693
CHINA Trader

Hangzhou FandaChem Co.,Ltd.

macitentan
Remarks: Purity: As coa | Package: As request | CustNote: 441798-33-0
TEL: 008657128800458
CHINA Trader

ATK CHEMICAL COMPANY LIMITED

N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide
Remarks: Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
TEL: 21-51877795
CHINA Reagent

career henan chemical co

macitentan
Remarks: Purity: 98% | Package: 1KG;100USD
TEL: 0371-86658258
CHINA Reagent

￥100.00/1KG