macitentan suppliers

macitentan

CAS:: 441798-33-0

MF:: C19H20Br2N6O4S

MW:: 588.27

Use：: Macitentan (also known as ACT-064992) received US FDA approval in October 2013 for the treatment of pulmonary arterial hypertension (PAH) (WHO group I) to delay disease progression. Treatment options include phosphodiesterase type 5 inhibitors, prostacyclins, and the endothelin receptor antagonists bosentan and ambrisentan. Macitentan was discovered through SAR studies starting with the bosentan structure with three main goals: (1) to increase potency for both endothelin receptor A and B (ETA and ETB) subtypes; (2) to improve tissue distribution to reach the target receptors; and (3) to avoid bile salt transport inhibition. Starting with the bosentan sulfonamido-pyrimidinyl central core, potency was increased 10-fold via incorporation of a bromopyrimidinyl ethylene glycol ether, as found in the clinical endothelin antagonist, T-0201. An aryl ether in bosentan was replaced with the bromophenyl group in macitentan, and a substituent on the 2-position of the central pyrimidine was replaced with hydrogen. Several sulfonamides and alkyl sulfamates were explored, with the propylsulfamate providing the best combination of in vitro potency, especially for ETB antagonism, and in vivo efficacy.

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You can find macitentan suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Seasons Biotechnology Co., Ltd.

Macitentan
Remarks: Purity: 99%HPLC | Package: Gram to Kilogram Class
CHINA Trader

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Macitentan.
Remarks: Purity: More Than 99%|Package: 1g
TEL: 010-87925929
CHINA Trader

Capot Chemical Co.,Ltd.

Macitentan
Remarks: Purity: 98%(Min,HPLC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
TEL: +86-（0）57185586718
CHINA Trader

Henan Tianfu Chemical Co.,Ltd.

macitentan
Remarks: Purity: 99% | Package: 25KG;5KG;1KG
TEL: 0371-+86-0371-55170693
CHINA Trader

career henan chemical co

macitentan
Remarks: Purity: 98% | Package: 1KG;100USD
TEL: 0371-86658258
CHINA Reagent

$100.00

Zhejiang ZETian Fine Chemicals Co. LTD

macitentan
Remarks: Purity: 0.99 | Package: 5KG;1KG
CHINA Trader

Shanghai Worldyang Chemical Co.,Ltd.

Macitentan
Remarks: Purity: 99% | Package: 1Kg/Bag;1USD
TEL: 021-+86-021-56795779
CHINA Trader

CONIER CHEM AND PHARMA LIMITED

macitentan
Remarks: Purity: 0.99 | Package: 100g,1kg
CHINA Trader

TargetMol Chemicals Inc.

Macitentan
Remarks: Purity: 99.81% | Package: 10mg;37USD|25mg;44USD|50mg;51USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
TEL: +1-781-999-5354
UNITED STATES Trader

$37.00

$44.00

$51.00

Shanghai UCHEM Inc.

Macitentan
Remarks: Purity: 马西替坦; | Package: 1308068-626-2 | CustNote: 0.99
TEL: +862156762820
CHINA Trader