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- CAS:
- 846-49-1
- MF:
- C15H10Cl2N2O2
- MW:
- 321.16
Properties
- Melting point::
- 166-168°C
- Boiling point::
- 533.8±50.0 °C(Predicted)
- Density :
- 1.4835 (rough estimate)
- refractive index :
- 1.6070 (estimate)
- Flash point::
- 11 °C
- storage temp. :
- −20°C
- solubility :
- Practically insoluble in water, sparingly soluble in ethanol (96 per cent), sparingly soluble or slightly soluble in methylene chloride.
- pka:
- pK1 1.3; pK2 11.5(at 25℃)
- Water Solubility :
- 54mg/L(temperature not stated)
- BCS Class:
- 1
- Stability::
- hygroscopic
- CAS DataBase Reference:
- 846-49-1(CAS DataBase Reference)
- NIST Chemistry Reference:
- Lorazepam(846-49-1)
- EPA Substance Registry System:
- Lorazepam (846-49-1)
SecurityInformation
- Symbol(GHS) :
-
GHS08
- Signal word :
- Warning
- Hazard statements :
- H361
- Precautionary statements :
- P201-P202-P280-P308+P313-P405-P501
- Hazard Codes :
- Xn,T,F
- Risk Statements :
- 63-39/23/24/25-23/24/25-11-36-20/21/22
- Safety Statements :
- 36/37-45-16
- RIDADR :
- UN 1230 3/PG 2
- WGK Germany :
- 3
- RTECS :
- DF0350000
- HS Code :
- 2933910000
- Toxicity:
- LD50 in mice, rats (mg/kg): 3178, >5000 orally (Owen)
- Use:
- Lorazepam, 7-chloro-5-(2-chlorophenyl)-3-dihydro-3-hydroxy-2H-1,4-benzodiazepine-2-one(Ativan), is the 2'-chloro derivative of oxazepam. In keepingwith overall SARs, the 2'-chloro substituent increases activity.As with oxazepam, metabolism is relatively rapid anduncomplicated because of the 3-hydroxyl group in the compound.Thus, it also has short half-life (2–6 hours) and similarpharmacological activity.
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