Loperamide suppliers

Loperamide

CAS:: 53179-11-6

MF:: C29H33ClN2O2

MW:: 477.04

Use：: Loperamide (Imodium) is a 4-phenylypiperidine with amethadone-like structure attached to the piperidine nitrogen. It acts as an antidiarrheal by directly binding tothe opiate receptors in the gut wall. Loperamide inhibitsacetylcholine and prostaglandin release, decreasing peristalsisand fluid secretion thus increasing the GI transit time andreducing the volume of fecal matter.Loperamide is sufficiently lipophilic to cross the blood-brain barrier, yet itdisplays no CNS-opioid effects. The reason for this is that itis actively pumped out of the brain via the P-glycoproteinpump (MDR1). Knockout mice with the P-glycoproteinpump genetically removed were given radiolabeled loperamideand sacrificed 4 hours later. The [3H]loperamideconcentrations were measured and compared with wild-typemice. A 13.5-fold increase in loperamide concentration wasfound in the brain of the knockouts. In addition, the micelacking the P-glycoprotein pump displayed pronouncedsigns of central opiate agonism. Loperamide is availableas 2-mg capsules for treatment of acute and chronic diarrhea.Recommended dosage is 4 mg initially, with 2 mgafter each loose stool for a maximum of 16 mg/d.

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You can find Loperamide suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Shaanxi Xianhe Biotech Co., Ltd

Loperamide
Remarks: Purity: 0.99|Package: 1KG
TEL: +86-17709210191
CHINA Trader

career henan chemical co

Loperamide
Remarks: Purity: 98% | Package: 1KG
TEL: 0371-86658258
CHINA Reagent

CONIER CHEM AND PHARMA LIMITED

loperamide
Remarks: Purity: 0.99 | Package: 1kg
CHINA Trader

Shaanxi Dideu Medichem Co. Ltd

Loperamide USP/EP/BP
Remarks: Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
TEL: +86-029-89586680
CHINA Trader