Lomerizine hydrochloride suppliers

Lomerizine hydrochloride

CAS:: 101477-54-7

MF:: C27H32Cl2F2N2O3

MW:: 541.46

SecurityInformation

Symbol(GHS) ：: GHS07,GHS09

Signal word ：: Warning

Hazard statements ：: H302-H410

Precautionary statements ：: P264-P270-P273-P301+P312-P391-P501

Hazard Codes ：: Xn,N

Risk Statements ：: 22-50

Safety Statements ：: 61

RIDADR ：: UN 3077 9 / PGIII

WGK Germany ：: 3

RTECS ：: TK9189000

HS Code ：: 29335990

Toxicity：: LD50 orally in mice: 300 mg/kg (Ohtaka)

Use：: Lomerizine hydrochloride was introduced as Teranas and Migsis in Japan for the treatment of migraine. It is the first in its class of dual sodium and calcium channel blockers to be marketed for this indication. It can be synthetically obtained by reductive amination of 2,3,4-trimethoxybenzaldehyde with the appropiate benzhydryl piperazine. In dogs, Lomerizine exerts a potent, selective and long-lasting vasodilation of cerebral arteries related to a combination of mechanisms, especially a functional block of L-type voltagesensitive calcium channels (L-VSCCs). Lomerizine increases cerebral blood flow compared to peripheral blood flow with only weak effects on systemic arterial blood pressure. Other mechanisms involved could be blockade of other VSCC and sodium channels, 5-HT2 and alpha-1 receptors. As a reducing agent of cortical spreading depression and neurogenic inflammation, Lomerizine was shown to be useful in migraine. In an open clinical study, it demonstrated efficacy in the treatment of cluster headache. Moreover, it may have utility in other neurological diseases such as cerebrovascular ischemia or cerebral infarction.

More▼

You can find Lomerizine hydrochloride suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

ATK CHEMICAL COMPANY LIMITED

Lomerizine hydrochloride
Remarks: Purity: 0.99 | Package: 5MG;10MG;50MG;100MG,1G,5G
TEL: 21-51877795
CHINA Reagent

Xiamen AmoyChem Co., Ltd

Lomerizine Hydrochloride
TEL: 592-+86-592-6051114
CHINA Service provider

CONIER CHEM AND PHARMA LIMITED

lomerizine hydrochloride
Remarks: Purity: 0.99 | Package: 1kg
CHINA Trader

career henan chemical co

Lomerizine hydrochloride
Remarks: Purity: 99% | Package: 1KG;7USD
TEL: 0371-86658258
CHINA Trader

￥7.00/1KG

Neostar United (Changzhou) Industrial Co., Ltd.

Lomerizine hydrochloride
Remarks: Purity: 0.99
TEL: 519-+86-519-519-85557386
CHINA Trader

SIMAGCHEM CORP

Lomerizine Hydrochloride
Remarks: Purity: 0.99 | Package: 1kg,5kg,25kgs,200kgs;bulk
CHINA Trader

Dideu Industries Group Limited

Lomerizine hydrochloride
Remarks: Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
TEL: 029-+86-29-89586680
CHINA Trader

AFINE CHEMICALS LIMITED

LOMERIZINE HYDROCHLORIDE
Remarks: Purity: 99% | Package: USP EP CP
TEL: 0571-85134551
CHINA Trader

Sinoway Industrial co., ltd.

Lomerizine hydrochloride
Remarks: Purity: 0.99 | Package: 25KG;5KG;1KG
TEL: 0592-5800732
CHINA Trader

Dayang Chem (Hangzhou) Co.,Ltd.

Lomerizine hydrochloride
Remarks: Purity: 0.95&0.99 | Package: 0.1KG;1KG;1000KG | CustNote: Wholesale price
TEL: 571-571-88938639
CHINA Trader