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ChemicalBook >> CAS DataBase List >>Lansoprazole

Lansoprazole suppliers

Lansoprazole

CAS:: 103577-45-3

MF:: C16H14F3N3O2S

MW:: 369.36

SecurityInformation

Symbol(GHS) ：: GHS07

Signal word ：: Warning

Hazard statements ：: H315-H319-H335

Precautionary statements ：: P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes ：: Xi

Risk Statements ：: 36/37/38

Safety Statements ：: 26-36

WGK Germany ：: 2

RTECS ：: DD9487500

HS Code ：: 29339900

Toxicity：: dog,LD,oral,> 2gm/kg (2000mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 387, 1993.

Use：: Lansoprazole is a proton pump inhibitor (PPI) similar to omeprazole that inactivates the hydrogen/potassium-stimulated ATPase pumps in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH. It is a potent inhibitor of gastric acidity which is widely used in the therapy of gastroesophageal reflux and peptic ulcer disease. Lansoprazole is a racemic mixture of (R)- and (S)-isomers. Dexlansoprazole is an isomer of lansoprazole that has a similar spectrum of activity and toxicities. Lansoprazole therapy is associated with a low rate of transient and asymptomatic serum aminotransferase elevations and is a reported, but very rare cause of clinically apparent liver injury. Lansoprazoles plasma elimination half-life is not proportional to the duration of the drugs effects (i. e. gastric acid suppression). The plasma elimination half-life is 1. 5 hours or less, and the effects of the drug last for over 24 hours after it has been given for 5 days or more. Lansoprazole is a prescription medicine used to treat: gastroesophageal reflux disease (GERD) erosive esophagitis stomach ulcers duodenal ulcers H. Pylori infections Zollinger-Ellison syndrome

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