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ChemicalBook >> CAS DataBase List >>Ketotifen fumarate

Ketotifen fumarate suppliers

Ketotifen fumarate

CAS:: 34580-14-8

MF:: C23H23NO5S

MW:: 425.5

SecurityInformation

Symbol(GHS) ：: GHS07

Signal word ：: Warning

Hazard statements ：: H302-H319

Precautionary statements ：: P264-P270-P280-P301+P312-P305+P351+P338-P337+P313

Hazard Codes ：: Xn,T

Risk Statements ：: 22-36/37/38-23/24/25

Safety Statements ：: 36-45-36/37/39-26

WGK Germany ：: 3

RTECS ：: DE8260000

HS Code ：: 29349990

Toxicity：: child,TDLo,oral,200ug/kg (0.2mg/kg),Drug Safety. Vol. 7, Pg. 387, 1992.

Use：: Ketotifen fumarate is a kind of strong anti-allergic drugs containing simultaneously of both tricyclic structure as well as piperidine structure. It is characterized by both a strong antagonism effect on histamine H1 receptor and inhibitory effect of the release of the mediator of allergic reaction. It can inhibit the release various kinds of mediators of mast cells, basophils and macrophages, including the release of slow reacting substances and other active substances. It also has antagonism effect on the calcium ion; can inhibit the activity of phosphodiesterase; increase the intracellular cAMP level inside mast cells. Moreover, it can also inhibiting the chemotaxis and inflammation of neutrophil with an effect 10 times as strong as that of chlorpheniramine, and it also has a long duration time which is better compared with sodium cromolyn. Ketotifen fumarate has therapeutic effect on both Ⅰ and Ⅲ type of allergic reaction. Its peak blood concentrations can sustain for 2 to 3 hours with a half-life of 22 hours during which 60% goes through urinary excretion, 40% goes through the fecal excretion. Children usually have a faster excretion rate of it than adults. Long-term treatment will not cause resistance. No rebound phenomenon will occur with interruption of treatment.

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You can find Ketotifen fumarate suppliers, manufacturers, and distributors from countries such as CHINA, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

QINGDAO HONG JIN CHEMCIAL CO.,LTD.