GSK1349572 suppliers

GSK1349572

CAS:: 1051375-16-6

MF:: C20H19F2N3O5

MW:: 419.38

Use：: In August 2013, the US FDA approved dolutegravir (also referred to as S/GSK1349572) for the treatment of HIV-1 infection in adults and children ages 12 years and older in combination with other antiretroviral drugs. Dolutegravir was approved in Canada in November 2013. HIV/AIDS remains a global epidemic with 35 million people infected, including 2.3 million new infections as of 2012. Dolutegravir joins raltegravir and elvitegravir (this chapter of ARMC) as the latest of three FDA-approved HIV integrase strand transfer inhibitors (INSTIs). Dolutegravir was discovered by rational design from a literature diketo acid HIV integrase inhibitor utilizing X-ray coordinates to predict ideal bond angles between the diketone and distal benzyl group. In dolutegravir, the monocyclic component of the reported inhibitor was replaced with the tricyclic carbamoyl pyridone moiety. The researchers postulated that the appropriate arrangement of three oxygens would permit chelation with two magnesium ions in the binding site thus affording improved potency. Ultimately, this arrangement along with further modifications afforded dolutegravir, a potent inhibitor of HIV integrase (IC50=1.7 nM).

More▼

You can find GSK1349572 suppliers, manufacturers, and distributors from countries such as CHINA, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

AFINE CHEMICALS LIMITED

DOLUTEGRAVIR
Remarks: Purity: 99% | Package: USP EP CP
TEL: 0571-85134551
CHINA Trader

Guangzhou Tengyue Chemical Co., Ltd.

Dolutegravir; DTG; GSK1349572
Remarks: Purity: 99% Purity (What/sapp: +86 18145728414) | Package: 10g;240USD
TEL: 86-18148706580
CHINA Trader

￥240.00/10g

Capot Chemical Co.,Ltd.

dolutegravir
Remarks: Purity: NLT 98% | Package: 1G;1KG;100KG
TEL: 571-571-85586718
CHINA Trader

Hangzhou FandaChem Co.,Ltd.

Dolutegravir
Remarks: Purity: as in COA | Package: as customers' requirements
TEL: 008657128800458
CHINA Trader

ATK CHEMICAL COMPANY LIMITED

Dolutegravir(GSK1349572)
Remarks: Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
TEL: 21-51877795
CHINA Reagent

career henan chemical co

GSK1349572
Remarks: Purity: 99% | Package: 1KG;6000USD
TEL: 0371-86658258
CHINA Reagent

￥6000.00/1KG

SHANDONG ZHI SHANG CHEMICAL CO.LTD

GSK1349572
Remarks: Purity: 0.99 | Package: 5KG;1KG
TEL: 0531-68652808
CHINA Trader

BOC Sciences

Dolutegravir (GSK1349572)
Remarks: Purity: >=98% | Package: 25mg | CustNote: BOC Sciences also provides custom synthesis services for Dolutegravir (GSK1349572).
UNITED STATES Trader

Chongqing Chemdad Co., Ltd

GSK1349572
Remarks: Purity: 0.98 | Package: 1kg，2kg，5kg，10kg，25kg
TEL: 023-+86-023-61398051
CHINA Trader

CONIER CHEM AND PHARMA LIMITED

gsk 1349572
Remarks: Purity: 0.99 | Package: 1kg
CHINA Trader