GDC-0084 suppliers

GDC-0084

CAS:: 1382979-44-3

MF:: C18H22N8O2

MW:: 382.42

Use：: Stumpf et al. at Genentech Inc. (Roche group) developed an efficient multikilogram process to synthesize the brain penetrant PI3K inhibitor, GDC‐0084, a potential drug candidate for the treatment of several brain cancers. An efficient Suzuki coupling reaction between a chloropyrimidine and an arylboronic ester using a palladium catalyst at low loading was reported. The optimized conditions were demonstrated on 6.75 kg of a chloropyrimidine intermediate, providing 7.49 kg of crude GDC‐0084 (94% yield, 99.4% HPLC purity). Using the commercially available XPhos Pd G2 catalyst, instead of the usual PdCl2(dppf)CH2Cl2 catalyst, it was possible to reduce the catalyst loading from 2 to 0.5 mol%. A final scavenging/recrystallization combination from Si‐Thiol (a solid‐supported resin) and acetic acid/water provided the crude GDC‐0084 with the required purity and polymorphic form (off‐white solid, 6.41 kg, 83% yield, 99.7% HPLC purity). Genentechs route to GDC‐0084 employing a pivotal Suzuki reaction.

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You can find GDC-0084 suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

ATK CHEMICAL COMPANY LIMITED

GDC-0084
Remarks: Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
TEL: 21-51877795
CHINA Reagent

BOC Sciences

GDC-0084
Remarks: Purity: 98% | Package: 300mg | CustNote: BOC Sciences also provides custom synthesis services for GDC-0084.
UNITED STATES Trader

career henan chemical co

5-[6,6-Dimethyl-4-(4-morpholinyl)-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purin-2-yl]-2-pyrimidinamine
Remarks: Purity: Min98% HPLC | Package: 1KG;1USD
TEL: 0371-86658258
CHINA Trader

￥1.00/1KG

TargetMol Chemicals Inc.

GDC0084
Remarks: Purity: >=95% | Package: 5mg;56USD|10mg;89USD|25mg;178USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
TEL: +1-781-999-5354
UNITED STATES Trader

Win-Win chemical CO., Limited

5-(6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purin-2-yl)pyrimidin-2-amine
Remarks: Purity: 98% | Package: 1g,5g,10g
TEL: 0577-64498589
CHINA Trader

Zhejiang J&C Biological Technology Co.,Limited

GDC-0084
Remarks: Purity: 99% | Package: 5KG;1KG | CustNote: GDC-0084
TEL: 1-2135480471
CHINA Trader

TargetMol Chemicals Inc.

GDC0084；RG7666;GDC-0084;GDC 0084
Remarks: Package: 1 mg；1 mL * 10mM (in DMSO)；10 mg；2 mg；25 mg；5 mg；50 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
TEL: +1-781-999-5354
UNITED STATES Reagent

LEAPCHEM CO., LTD.

GDC-0084
Remarks: Purity: 0 | Package: 1g; 5g; 25g; 1kg; 5kg; 25kg | CustNote: 0
TEL: 852-30606658
CHINA Trader

Aladdin Scientific

Paxalisib (GDC-0084)
Remarks: Purity: 99% | Package: $254.9/5mg;$408.9/10mg;$817.9/25mg;$1510.9/50mg;Bulk package | CustNote: 99%
TEL: 552-7181
UNITED STATES Trader

Amadis Chemical Company Limited

GDC-0084
Remarks: Purity: 0.97 | Package: mgs,gs,kgs | CustNote: A909398
TEL: 571-89925085
CHINA Reagent