Fasudil hydrochloride suppliers

Fasudil hydrochloride

CAS:: 105628-07-7

MF:: C14H18ClN3O2S

MW:: 327.83

SecurityInformation

Symbol(GHS) ：: GHS07

Signal word ：: Warning

Hazard statements ：: H302

Precautionary statements ：: P264-P270-P301+P312+P330-P501-P301+P312a-P330-P501a

Risk Statements ：: 22

Safety Statements ：: 36-60

WGK Germany ：: 3

RTECS ：: HM4031166

HS Code ：: 29339900

Toxicity：: LD50 in mice, rats (mg/kg): 67.5, 59.9 i.v.; 124.5, 123.2 s.c.; 273.9, 335.0 orally (Koga)

Use：: Fasudil Hydrochloride is an isoquinoline sulfonamide derivative which can relax separated cerebral blood vessels, inhibit the shrinkage of separated blood vessels caused by calcium influx, inhibit different mechanisms of brain blood vessel contraction from contractile agents, and inhibit intracellular calcium ion activity without reducing calcium ion concentration. Fasudil Hydrochloride is an RHO kinase inhibitor which dilates vessels, reduces tension of endothelial cells, and improves microcirculation of brain tissue without producing or exacerbating diversion of blood to the brain, by increasing activity of myosin light chain phosphatase. At the same time, it can protect nerves against apoptosis and promote their regeneration. Fasudil Hydrochloride promotes recovery of neural function and reduces clinical symptoms.

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Hebei Chuanghai Biotechnology Co., Ltd