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ChemicalBook >> CAS DataBase List >>Etodolac

Etodolac suppliers

Etodolac

CAS:: 41340-25-4

MF:: C17H21NO3

MW:: 287.35

SecurityInformation

Symbol(GHS) ：: GHS06

Signal word ：: Danger

Hazard statements ：: H301

Precautionary statements ：: P264-P270-P301+P310-P405-P501

Hazard Codes ：: T,Xi

Risk Statements ：: 23/24/25-40-36-25-36/37/38

Safety Statements ：: 22-36-45-26-36/37

RIDADR ：: 3249

WGK Germany ：: 3

RTECS ：: UQ0360000

HazardClass ：: 6.1(b)

PackingGroup ：: III

HS Code ：: 29349990

Use：: Etodolac (Lodine, Ultradol), a chiral, COX-2 selectiveNSAID drug that is marketed as a racemate, possesses an indolering as the aryl portion of this group of NSAID drugs.It shares many similar properties of this group and is indicatedfor short- and long-term management of pain and OA.Similar to ketorolac, etodolac exhibits several uniqueenantioselective pharmacokinetic properties. For example,the “inactive” (R)-enantiomer has approximately a 10-foldhigher plasma concentration than the active (S)-enantiomer.Furthermore, the active (S)-enantiomer is less protein boundthan its (R)-enantiomer and therefore has a very large volumeof distribution. It is well absorbed with an elimination halflifeof 6 to 8 hours. Etodolac is extensively metabolized intothree major inactive metabolites, 6-hydroxy etodolac (via aromatichydroxylation), 7-hydroxy-etodolac (via aromatic hydroxylation),and 8-(1'-hydroxylethyl) etodolac (via benzylichydroxylation), which are eliminated as the correspondingether glucuronides. Its unstable, acyl glucuronide, however,is subject to enterohepatic circulation and reactivation tothe parent drug, similar to other NSAIDS in this class.

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Hebei Chuanghai Biotechnology Co,.LTD