Eggmanone suppliers

Eggmanone

CAS:: 505068-32-6

MF:: C20H20N2O2S3

MW:: 416.58

Use：: Type 4 cyclic nucleotide phosphodiesterase (PDE4) selectively inactivates the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. PDE4 has been reported to play a key regulatory role in Hedgehog signaling downstream of smoothened and, thus, represents a potential therapeutic target for Hedgehog-dependent cancers. Eggmanone is a selective inhibitor of PDE4 (IC50 = 72 nM) that antagonizes the Hedgehog signaling pathway. It demonstrates 40- to 50-fold lower potency at PDE3, PDE10, and PDE11 (IC50s = 3, 3.05, and 4.08 μM, respectively). Inhibition of PDE4 activity via eggmanone was shown to activate localized protein kinase A signaling, which, in turn, regulates Gli processing and translocation.[Cayman Chemical]

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You can find Eggmanone suppliers, manufacturers, and distributors from countries such as United States, China and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

TargetMol Chemicals Inc.

Eggmanone
Remarks: Package: 10mg;1580USD|5mg;890USD|1mg;198USD
TEL: +1-781-999-5354
UNITED STATES Trader

$2290.00

$1290.00

$287.00

BOC Sciences

Eggmanone
Remarks: Purity: >=98% by HPLC | CustNote: Please reach out to us for more information about custom solutions.
TEL: 16314854226
UNITED STATES Reagent

Aladdin Scientific

Eggmanone
Remarks: Purity: >=98%(HPLC) | Package: $139.9/10mg;$584.9/50mg;Bulk package | CustNote: 98%(HPLC)
TEL: 552-7181
UNITED STATES Trader

Tocris Bioscience

5,6,7,8-Tetrahydro-3-(2-methyl-2-propen-1-yl)-2-[[2-oxo-2-(2-thienyl)ethyl]thio]-[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
Remarks: Brand: Tocris Bioscience | Product Number: 5695 | Purity: ≥98% (HPLC)
TEL: +44 (0) 117 916 3333
UNITED KINGDOM Trader

$159.00/10 mg

$669.00/50 mg

DC Chemicals