Doxercalciferol suppliers

Doxercalciferol

CAS:: 54573-75-0

MF:: C28H44O2

MW:: 412.65

SecurityInformation

Symbol(GHS) ：: GHS06

Signal word ：: Danger

Hazard statements ：: H300

Precautionary statements ：: P264-P301+P310

Hazard Codes ：: T+

Risk Statements ：: 28

Safety Statements ：: 28-36/37-45

RIDADR ：: UN 2811 6.1 / PGIII

WGK Germany ：: 3

RTECS ：: VS2950000

HS Code ：: 2936299055

Toxicity：: LD50 orally in rats: 3.5-6.5 mg/kg (Sjden)

Use：: Doxercalciferol is a synthetic vitamin D2 analog introduced in the US as Hectorol for the treatment of secondary hyperparathyroidism (SHPT) in patients with end-stage renal failure. It is actually 1-alpha-hydroxyvitamin D2 (one-alpha- D2) and can be synthesized by direct hydroxylation of vitamin D2 tosylate or in 5 steps from ergosterol. Doxercalciferol itself is inactive until metabolized by the liver into active 1,24-dihydroxyvitamin D2, showing a pharmacokinetic profile similar to calcitriol. During placebo-controlled clinical trials, patients with moderate to severe SHPT were treated with 1-alpha-D2 (10 μg doses) for 16 to 24 weeks; in 9 patients out of 10, blood levels of parathyroid hormone were considerably reduced, so maintaining a good control of the parathyroid hyperplasia. Moreover, only a moderate tendency to raise calcium and phosphate was observed. Doxercalciferol is orally-active and less toxic than other vitamin D analogs like alfacalcidol; it shows differentially controlled effects and has an improved safety profile compared to calcitriol.Doxercalciferol is a synthetic vitamin D2 analog introduced in the US as Hectorol for the treatment of secondary hyperparathyroidism (SHPT) in patients with end-stage renal failure. It is actually 1-alpha-hydroxyvitamin D2 (one-alpha- D2) and can be synthesized by direct hydroxylation of vitamin D2 tosylate or in 5 steps from ergosterol. Doxercalciferol itself is inactive until metabolized by the liver into active 1,24-dihydroxyvitamin D2, showing a pharmacokinetic profile similar to calcitriol. During placebo-controlled clinical trials, patients with moderate to severe SHPT were treated with 1-alpha-D2 (10 μg doses) for 16 to 24 weeks; in 9 patients out of 10, blood levels of parathyroid hormone were considerably reduced, so maintaining a good control of the parathyroid hyperplasia. Moreover, only a moderate tendency to raise calcium and phosphate was observed. Doxercalciferol is orally-active and less toxic than other vitamin D analogs like alfacalcidol; it shows differentially controlled effects and has an improved safety profile compared to calcitriol.Doxercalciferol is a synthetic vitamin D2 analog introduced in the US as Hectorol for the treatment of secondary hyperparathyroidism (SHPT) in patients with end-stage renal failure. It is actually 1-alpha-hydroxyvitamin D2 (one-alpha- D2) and can be synthesized by direct hydroxylation of vitamin D2 tosylate or in 5 steps from ergosterol. Doxercalciferol itself is inactive until metabolized by the liver into active 1,24-dihydroxyvitamin D2, showing a pharmacokinetic profile similar to calcitriol. During placebo-controlled clinical trials, patients with moderate to severe SHPT were treated with 1-alpha-D2 (10 μg doses) for 16 to 24 weeks; in 9 patients out of 10, blood levels of parathyroid hormone were considerably reduced, so maintaining a good control of the parathyroid hyperplasia. Moreover, only a moderate tendency to raise calcium and phosphate was observed. Doxercalciferol is orally-active and less toxic than other vitamin D analogs like alfacalcidol; it shows differentially controlled effects and has an improved safety profile compared to calcitriol.Doxercalciferol isCrystalline Solid

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You can find Doxercalciferol suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

ChemExpress

Doxercalciferol
Remarks: Purity: 99% | Package: 100g;1kg;10kg
TEL: +86-021-58950125
CHINA Manufacturer

Capot Chemical Co.,Ltd.

Doxercalciferol
Remarks: Purity: 98%(Min,HPLC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
TEL: 571-85586718
CHINA Trader

Shanghai Daken Advanced Materials Co.,Ltd

Doxercalciferol
Remarks: Purity: 99% | Package: 1KG;5KG;100KG
TEL: 371-+86-371-66670886
CHINA Trader

Henan Tianfu Chemical Co.,Ltd.

Doxercalciferol
Remarks: Purity: 99% | Package: 25KG;5KG;1KG
TEL: 0371-+86-0371-55170693
CHINA Trader

career henan chemical co

Doxercalciferol
Remarks: Purity: 99% | Package: 1KG;1USD
TEL: 0371-86658258
CHINA Reagent

￥1.00/1KG

BOC Sciences

Doxercalciferol
Remarks: Purity: 0.98 | Package: 25mg | CustNote: BOC Sciences also provides custom synthesis services for Doxercalciferol.
UNITED STATES Trader

CONIER CHEM AND PHARMA LIMITED

doxercalciferol
Remarks: Purity: 0.99 | Package: 1kg
CHINA Trader

Shaanxi Dideu Medichem Co. Ltd

Doxercalciferol
Remarks: Purity: 99.0% | Package: 100g;1kg;5kg;25kg
TEL: +86-29-87569266
CHINA Trader

Neostar United (Changzhou) Industrial Co., Ltd.

Doxercalciferol
Remarks: Purity: 0.99 | CustNote: 1KG,5KG,25KG,200KG
TEL: 0519-85551759
CHINA Trader

SIMAGCHEM CORP

1Alpha-Oh-D2
Remarks: Purity: 0.99 | Package: 1kg,5kg,25kgs,200kgs;bulk
CHINA Trader