Chlorhexidine digluconate suppliers

Chlorhexidine digluconate

CAS:: 18472-51-0

MF:: C22H30Cl2N10.2C6H12O7

MW:: 897.76

SecurityInformation

Symbol(GHS) ：: GHS05,GHS09

Signal word ：: Danger

Hazard statements ：: H318-H410

Precautionary statements ：: P273-P280-P305+P351+P338-P391-P501

Hazard Codes ：: N

Risk Statements ：: 50/53

Safety Statements ：: 61

RIDADR ：: UN 3082 9 / PGIII

WGK Germany ：: -

RTECS ：: DU1950000

TSCA ：: Yes

HazardClass ：: 9

PackingGroup ：: III

HS Code ：: 29252900

Toxicity：: LD50 in mice (mg/kg): 22 i.v.; 1800 orally (Foulkes)

Use：: Chlorhexidine digluconate solution is a bis(biguanide) family cationic broad spectrum antibiotic that is available in a range of concentrations and has been safely used for over 40 years for a variety of health-related applications; but its specific use for umbilical cord care was uniquely tested in three clinical trials in Nepal, Bangladesh, and Pakistan, in the form of 7.1% chlorhexidine digluconate (CHX). Given the promising results of the trials, in 2013 the World Health Organization (WHO) added CHX to its Model List of Essential Medicines for Children; and in 2014 the WHO issued a new guideline on umbilical cord care, which included a formal recommendation on the use of chlorhexidine. Chlorhexidine digluconate is a broad spectrum antiseptic. Its mechanism of action involves destabilization of the outer bacterial membrane. It is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria.It has both bactericidal and bacteriostatic mechanisms of action, the mechanism of action being membrane disruption, not ATPase inactivation as previously thought.It is also useful against fungi and enveloped viruses, though this has not been extensively investigated. Chlorhexidine is harmful in high concentrations, but is used safely in low concentrations in many products, such as mouthwash and contact lens solutions.

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