Cemandil sodium salt suppliers

Cemandil sodium salt

CAS:: 42540-40-9

MF:: C19H17N6NaO6S2

MW:: 512.49

Use：: Cefamandole (Mandol) nafate is the formate ester ofcefamandole, a semisynthetic cephalosporin that incorporates D-mandelic acids as the acyl portion and a thiol-containingheterocycle (5-thio-1,2,3,4-tetrazole) in place of the acetoxylfunction on the C-3 methylene carbon atom. Esterification ofthe α-hydroxyl group of the D-mandeloyl function overcomesthe instability of cefamandole in solid-state dosage formsand provides satisfactory concentrations of the parent antibioticin vivo through spontaneous hydrolysis of the ester atneutral to alkaline pH. Cefamandole is the first second-generationcephalosporin to be marketed in the United States.The D-mandeloyl moiety of cefamandole appears toconfer resistance to a few β-lactamases, since some β-lactamase–producing, Gram-negative bacteria (particularlyEnterobacteriaceae) that show resistance to cefazolin andother first-generation cephalosporins are sensitive tocefamandole. Additionally, it is active against some ampicillin-resistant strains of Neisseria and Haemophilus spp.Although resistance to β-lactamases may be a factor in determiningthe sensitivity of individual bacterial strains tocefamandole, an early study indicated that other factors,such as permeability and intrinsic activity, are frequentlymore important. The L-mandeloyl isomer is significantlyless active than the D-isomer.Cefamandole nafate is very unstable in solution andhydrolyzes rapidly to release cefamandole and formate.There is no loss of potency, however, when such solutionsare stored for 24 hours at room temperature or up to 96hours when refrigerated. Air oxidation of the released formateto carbon dioxide can cause pressure to build up in theinjection vial.The D-mandeloyl moiety of Cemandil sodium salt appears toconfer resistance to a few β-lactamases, since some β-lactamase–producing, Gram-negative bacteria (particularlyEnterobacteriaceae) that show resistance to cefazolin andother first-generation cephalosporins are sensitive tocefamandole. Additionally, it is active against some ampicillin-resistant strains of Neisseria and Haemophilus spp.Although resistance to β-lactamases may be a factor in determiningthe sensitivity of individual bacterial strains tocefamandole, an early study indicated that other factors,such as permeability and intrinsic activity, are frequentlymore important. The L-mandeloyl isomer is significantlyless active than the D-isomer.

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You can find Cemandil sodium salt suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Shaanxi TNJONE Pharmaceutical Co., Ltd

Cefamandole Nafate
Remarks: Purity: 99% | Package: 1kg
CHINA Trader

￥0.00/1kg

Hebei Ganmiao New material Technology Co., LTD

Cemandil sodium salt
Remarks: Purity: 99.9% | Package: 1kg;10USD|10kg;9USD|100kg;7USD
TEL: 17332992504
CHINA Trader

￥10.00/1kg

￥9.00/10kg

￥7.00/100kg

Henan Tianfu Chemical Co.,Ltd.

Cefamandole Nafate API
Remarks: Purity: 99% | Package: 25KG;5KG;1KG
TEL: 0371-+86-0371-55170693
CHINA Trader

career henan chemical co

Cemandil sodium salt
Remarks: Purity: 99% | Package: 3KG;3USD
TEL: 0371-86658258
CHINA Reagent

￥3.00/3KG

Xiamen AmoyChem Co., Ltd

Cefamandole
TEL: 86-5926051114
CHINA Service provider

CONIER CHEM AND PHARMA LIMITED

cemandil sodium salt
Remarks: Purity: 0.99 | Package: 1kg
CHINA Trader

SIMAGCHEM CORP

Cefamandole Nafate
Remarks: Purity: 0.99 | Package: 1kg,5kg,25kgs,200kgs;bulk
CHINA Trader

Hefei TNJ Chemical Industry Co.,Ltd.

sodium [6R-[6α,7β(R*)]]-7-[[(formyloxy)phenylacetyl]amino]...
TEL: 0551-65418671
CHINA Reagent

Shaanxi Dideu Medichem Co. Ltd

Cemandil sodium salt USP/EP/BP
Remarks: Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
TEL: +86-029-89586680
CHINA Trader

AFINE CHEMICALS LIMITED

Cemandil sodium salt
Remarks: Purity: 99% | Package: USP EP CP
TEL: 0571-85134551
CHINA Trader