Camtobell hydrochloride suppliers

Camtobell hydrochloride

CAS:: 213819-48-8

MF:: C25H28ClN3O4

MW:: 469.97

Use：: Camtobell hydrochloride, a DNA topoisomerase I inhibitor, is an analog of camptothecin. It was launched in the Republic of Korea as an injectable formulation for the treatment of ovarian and small cell lung cancer. Although camptothecin exhibits potent antineoplastic activity in vitro, its clinical application is hampered by severe toxicity and poor water solubility. Several synthetic and semi-synthetic analogs of camptothecin with improved solubility and lower toxicity have been developed over the past two decades. Two drugs from this class, topotecan and irinotecan, have been launched in previous years and belotecan is the newest member to reach the market. Camtobell hydrochloride is prepared by a two-step semi-synthesis starting from camptothecin, first by converting to 7-methylcamptothecin via a free-radical methylation reaction using a combination of acetic acid, tert-butylhydroperoxide, ferrous sulfate and sulfuric acid, and subsequently, in the second step, a Mannich reaction with isopropylamine hydrochloride and dimethylsulfoxide. A total synthesis of belotecan in seventeen steps starting from ethyl acetopyruvate is also reported. Belotecan inhibits topoisomerase I with approximately equal potency as camptothecin and about 3-fold higher potency than topotecan, with respective IC50 values of 0.119, 0.123 and 0.33 μg/mL. Its cytotoxic activity is comparable to that of camptothecin, with IC50 values ranging from 2 ng/mL to 2 μg/mL against 26 different human cancer cell lines. In studies using human tumor xenografts in nude mice, 80-100 mg/ kg of belotecan dosed every four days for four doses produced 67 to 94% tumor regression rates against HT-29, WIDR and CX-1 colon, LX-1 lung, MX-1 breast and SKOV-3 ovarian carcinomas. Pharmacokinetic studies of camtobell hydrochloride in rats at intravenous doses of 2.6–8.9 mg/kg demonstrated that both Cmax and AUC increased in a dose-dependent manner. Total clearances, volumes of distribution and mean residence times did not change significantly with increasing doses. The elimination half-life ranged between 9.2 to 11.2 hours. In a Phase I study of camtobell hydrochloride, the fraction of renal clearance was found to be 33.1 to 50.3%, and the protein-binding fraction was 53 to 87%. Approximately 9.5% of the administered dose was excreted via the hepatobiliary system. In clinical studies involving 20 patients with recurrent or refractory ovarian cancer, intravenous administration of 0.5 mg/m2/day of belotecan for 5 days every 3 weeks over a median of six dosing cycles resulted in an overall response rate of 45%. All patients had grade 3 or 4 neutropenia as the most significant adverse event.

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You can find Camtobell hydrochloride suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

ATK CHEMICAL COMPANY LIMITED

Camtobell hydrochloride
Remarks: Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
TEL: 21-51877795
CHINA Reagent

career henan chemical co

Camtobell hydrochloride
Remarks: Purity: 99% | Package: 3ASSAYS;3USD
TEL: 0371-86658258
CHINA Reagent

￥3.00/3ASSAYS

BOC Sciences

CKD 602
Remarks: Purity: >=98% by HPLC | Package: 20mg | CustNote: BOC Sciences also provides custom synthesis services for CKD 602.
UNITED STATES Trader

CONIER CHEM AND PHARMA LIMITED

camtobell hydrochloride
Remarks: Purity: 0.99 | Package: 1kg
CHINA Trader

Zhengzhou Alfa Chemical Co.,Ltd

Camtobell hydrochloride
Remarks: Purity: 98% | Package: 5g; 25g; 100g; 500g; 1kg; 25kg
TEL: 0371-
CHINA Trader

TargetMol Chemicals Inc.

Belotecan hydrochloride
Remarks: Purity: >=95% | Package: 5mg;38USD|10mg;58USD|25mg;93USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
TEL: +1-781-999-5354
UNITED STATES Trader

Apeloa Pharmaceutical Co., Ltd.

Camtobell hydrochloride
Remarks: Purity: 0.98 | Package: 5KG;1KG
TEL: +86-0571-87635730
CHINA Trader

Finetech Industry Limited

Belotecan Hydrochloride
Remarks: Purity: 98% | Package: 1g,10g,25g,100g,500g,1kg
TEL: +86-27-87465837
CHINA Trader

Zhejiang J&C Biological Technology Co.,Limited

Camtobell hydrochloride
Remarks: Purity: 99% | Package: 5KG;1KG | CustNote: Camtobell hydrochloride
TEL: 1-2135480471
CHINA Trader

Alfa Chemistry

Camtobell hydrochloride
Remarks: CustNote: https://www.alfa-chemistry.com/cas_213819-48-8.htm
TEL: 15166625404
UNITED STATES Reagent