Trimethoprim suppliers

Trimethoprim

CAS:: 738-70-5

MF:: C14H18N4O3

MW:: 290.32

SecurityInformation

Symbol(GHS) ：: GHS07

Signal word ：: Warning

Hazard statements ：: H302

Precautionary statements ：: P264-P270-P301+P312-P501

Hazard Codes ：: T

Risk Statements ：: 25

Safety Statements ：: 45-24/25

RIDADR ：: 3249

WGK Germany ：: 3

RTECS ：: UV8225000

F ：: 8-10-21

HazardClass ：: 6.1(b)

PackingGroup ：: III

HS Code ：: 29335995

Toxicity：: LD50 orally in mice: 7000 mg/kg (Yamamoto)

Use：: Trimethoprim (5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine or 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine) is closely related to several antimalarialsbut does not have good antimalarial activity by itself; it is,however, a potent antibacterial. Originally introduced incombination with sulfamethoxazole, it is now available as asingle agent.Approved by the FDA in 1980, trimethoprim as a singleagent is used only for the treatment of uncomplicatedurinary tract infections. The argument for trimethoprim asa single agent was summarized in 1979 by Wormser andDeutsch. They point out that several studies comparingtrimethoprim with TMP–SMX for the treatment ofchronic urinary tract infections found no statistically relevantdifference between the two courses of therapy.The concern is that when used as a single agent, bacterianow susceptible to trimethoprim will rapidly developresistance. In combination with a sulfonamide, however,the bacteria will be less likely to do so. That is, they willnot survive long enough to easily develop resistance toboth drugs.

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