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ChemicalBook >> CAS DataBase List >>Pyrimethamine

Pyrimethamine suppliers

Pyrimethamine

CAS:: 58-14-0

MF:: C12H13ClN4

MW:: 248.71

SecurityInformation

Symbol(GHS) ：: GHS07

Signal word ：: Warning

Hazard statements ：: H302

Precautionary statements ：: P264-P270-P301+P312-P501

Hazard Codes ：: Xn

Risk Statements ：: 22-36

Safety Statements ：: 26

RIDADR ：: 3249

WGK Germany ：: 3

RTECS ：: UV8140000

HazardClass ：: 6.1(b)

PackingGroup ：: III

HS Code ：: 29335990

Hazardous Substances Data：: 58-14-0(Hazardous Substances Data)

Toxicity：: LD50 oral in rat: 440mg/kg

Use：: For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine. Pyrimethamine is a dihydrofolate reductase inhibitor, like the biguanides, and is structurally related to trimethoprim. It is seldom used alone. Pyrimethamine in fixed combinations with dapsone or sulfadoxine is used for treatment and prophylaxis of chloroquine-resistant falciparum malaria. The synergistic activities of pyrimethamine and sulfonamides are similar to those of trimethoprim/sulfonamide combinations. Resistant strains of Plasmodium falciparum have appeared world wide. Prophylaxis against falciparum malaria with pyrimethamine alone is therefore not recommended. Most strains of Plasmodium vivax have remained sensitive. Pyrimethamine is also used in combination with a sulfonamide for the treatment of Toxoplasmosis. It is slowly absorbed from the gastrointestinal tract with peak plasma levels 46 hours after dosing. Pyrimethamine is bound to plasma proteins and is extensively metabolized before excretion. Its elimination half-life is 35 days.

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You can find Pyrimethamine suppliers, manufacturers, and distributors from countries such as CHINA, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Hebei Weibang Biotechnology Co., Ltd