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ChemicalBook >> CAS DataBase List >>Leflunomide

Leflunomide suppliers

Leflunomide

CAS:: 75706-12-6

MF:: C12H9F3N2O2

MW:: 270.21

SecurityInformation

Symbol(GHS) ：: GHS06

Signal word ：: Danger

Hazard statements ：: H301-H315-H319-H335

Precautionary statements ：: P261-P264-P270-P301+P310-P302+P352-P305+P351+P338

Hazard Codes ：: Xn,Xi

Risk Statements ：: 22-36/37/38

Safety Statements ：: 26-36

RIDADR ：: UN 2811 6.1/PG 3

WGK Germany ：: 3

RTECS ：: NY2354200

HazardClass ：: 6.1

PackingGroup ：: III

HS Code ：: 2934990002

Use：: Leflunomide (Arava), an isoxazole prodrug, is an orally activeDMARD marketed in 1998 for the treatment of RA. Itis well absorbed and extensively metabolized in vivo to itsactive metabolite, 2-cyano-3-hydroxy-2-buteneamide (teriflunomide),resulting from a reductive ring opening of theisoxazole ring. Unlike MTX, teriflunomideblocks T-cell proliferation by inhibiting dihydroorotate dehydrogenase,the rate-limiting enzyme in the de novobiosynthesis of pyrimidine that is believed to be responsiblefor the immunosuppressive properties of leflunomide.For this reason, it is not surprising that leflunomide has avery comparable therapeutic efficacy to the first-lineDMARD, MTX as shown in several extended open clinicaltrials. However, even though leflunomide is well toleratedlike MTX, several cases of toxic neuropathy have beenobserved during its use, thus careful monitoring of the patient’sneurological status during treatment is mandatory.Like MTX, leflunomide is contraindicated in pregnancy orin women considering pregnancy.

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You can find Leflunomide suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Hebei Weibang Biotechnology Co., Ltd