L-Thyroxine suppliers

L-Thyroxine

CAS:: 51-48-9

MF:: C15H11I4NO4

MW:: 776.87

Use：: L-thyroxine is the major hormone derived from the thyroid gland. It is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines(diiodotyrosine)in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine that exerts a broad spectrum of stimulatory effects on cell metabolism. It is mainly used for the treatment of hypothyroidism, goiter, chronic lymphocytic thyroiditis, myxedema coma, and stupor[1]. The thyroid gland is responsible for the synthesis, storage and release of metabolic hormones including iodine-containing thyroxine(T4) and triiodothyroxine(T3). These hormones are crucial in the regulation of many metabolic processes and are vital for normal growth and development. They are also involved in calorigenic, cardiovascular and metabolic effects. The hormones exert their effects presumably by activating gene transcription of messenger RNA and proteins. To do so, they enter the cell nucleus and bind to DNA-bound thyroid receptors, which regulate gene transcription[2, 3].

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