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ChemicalBook >> CAS DataBase List >>Gallic acid

Gallic acid suppliers

Gallic acid

CAS:: 149-91-7

MF:: C7H6O5

MW:: 170.12

SecurityInformation

Symbol(GHS) ：: GHS07

Signal word ：: Warning

Hazard statements ：: H315-H319-H335

Precautionary statements ：: P302+P352-P305+P351+P338

Hazard Codes ：: Xi

Risk Statements ：: 36/37/38

Safety Statements ：: 26-36-24/25-37/39

WGK Germany ：: 2

RTECS ：: LW7525000

F ：: 8-9-23

TSCA ：: Yes

HS Code ：: 29182900

Toxicity：: LD50 in rabbits (g/kg): 5.0 orally (Dollahite)

Use：: The production of gallic acid is challenging. Conventionally, it has been produced by acid hydrolysis of tannic acid. However, this process is expensive due to low yields and high impurities. To overcome this problem, microbial production of gallic acid has been suggested. For example, in a solid-state fermentation of Teri pod cover powder containing tannin using Rhizopus oryzae, a yield of 90.9 % based on the tannin content of 58 % of the substrate was observed. In a submerged culture of Aspergillus aceleatus DBF9 growing on a medium with 3 % tannin, a maximal product concentration of 6.8 g.L-1 was reported. With tannic acid, even higher product concentrations of up to 25 g.L-1, a yield of 0.83 g of gallic acid per gram of tannic acid, and a productivity of 0,56 g.L-1.h-1 were shown using Apergillus fischeri MTCC 150 in submerged cultivation. An alternative is the enzymatic hydrolysis of tannic acids using tannase produced by microorganisms (e.g. Aspergillus fischeri or R. oryzae). For example, propyl gallate could be produced using a tannase from Emericela nidulans immobilized on ionic and covalent supports.

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