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CHLORDIAZEPOXIDE HYDROCHLORIDE suppliers
- CAS:
- 438-41-5
- MF:
- C16H15Cl2N3O
- MW:
- 336.22
Properties
- Melting point:：
- 213°
- storage temp. ：
- 2-8°C
- solubility ：
- Soluble in water, sparingly soluble in ethanol (96 per cent).
- Stability:：
- Stable. Incompatible with strong oxidizing agents.
- CAS DataBase Reference：
- 438-41-5(CAS DataBase Reference)
- EPA Substance Registry System：
- Chlordiazepoxide hydrochloride (438-41-5)
SecurityInformation
- Symbol(GHS) ：
-
GHS07,GHS08
- Signal word ：
- Warning
- Hazard statements ：
- H302-H361fd
- Precautionary statements ：
- P201-P301+P312+P330-P308+P313
- Hazard Codes ：
- Xn
- Risk Statements ：
- 22-62-63-68
- Safety Statements ：
- 22-36/37
- WGK Germany ：
- 3
- RTECS ：
- DE9450000
- HS Code ：
- 2933910000
- Toxicity：
- LD50 oral in rabbit: 590mg/kg
- Use：
- Chlordiazepoxide hydrochloride, 7-chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine4-oxide monohydrochloride (Librium), is well absorbedafter oral administration. Peak plasma levels are reachedin 2 to 4 hours. The half-life of chlordiazepoxide is 6 to30 hours. N-demethylation and hydrolysis of the condensedamidino group are rapid and extensive, producing demoxepamas a major metabolite. Demoxepam can undergo fourdifferent metabolic fates. It is converted principally to itsactive metabolite nordazepam, which is also a major activemetabolite of diazepam, clorazepate, and prazepam.Nordazepam, in turn, is converted principally to active oxazepam(marketed separately), which conjugated to the excretedglucuronide. Because of the long half-life of parentdrug and its active metabolites, this drug is long acting andself-tapering. As with diazepam (vide infra), repeated administrationof chlordiazepoxide can result in accumulationof parent drug and its active metabolites, and thus cause excessivesedation.
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