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ChemicalBook >> CAS DataBase List >>8-Hydroxyquinoline

8-Hydroxyquinoline suppliers

8-Hydroxyquinoline

CAS:: 148-24-3

MF:: C9H7NO

MW:: 145.16

SecurityInformation

Symbol(GHS) ：: GHS05,GHS06,GHS08,GHS09

Signal word ：: Danger

Hazard statements ：: H301-H317-H318-H360D-H410

Precautionary statements ：: P202-P273-P280-P301+P310-P302+P352-P305+P351+P338

Hazard Codes ：: Xn,Xi

Risk Statements ：: 22-68-36/37/38

Safety Statements ：: 45-36/37/39-26-36

RIDADR ：: 2811

WGK Germany ：: 3

RTECS ：: VC4200000

Hazard Note ：: Harmful/Irritant

TSCA ：: Yes

HazardClass ：: 9

PackingGroup ：: III

HS Code ：: 29334990

Toxicity：: An LD50 value of 1,200mg/kg was reported for oral administration of 8-hydroxyquinoline to rats (straidsex unspecified; AAPCO, 1966);a value of 48 mg/kg was reported for intraperitoneal administration to mice (strain/sex unspecxed; Bernstein et al., 1963).

Use：: 8-Hydroxyquinoline (8HQ) is an intermediate of halogenated quinoline anti-amebic drugs, including quiniodoform, clioquinoline, diiodoquinoline and the like. These drugs exert anti-amebic effects by inhibiting intestinal commensal bacteria, and are effective against amoebic dysentery, but have no effect on extra-intestinal amoebic parasites.8HQ is a small planar molecule with a lipophilic effect and a metal chelating ability. As a result, 8HQ and its derivatives hold medicinal properties such as antineurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic activities.

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