6-Thioguanine suppliers

6-Thioguanine

CAS:: 154-42-7

MF:: C5H5N5S

MW:: 167.19

SecurityInformation

Symbol(GHS) ：: GHS06

Signal word ：: Danger

Hazard statements ：: H301

Precautionary statements ：: P301+P310

Hazard Codes ：: T,Xi

Risk Statements ：: 25-23/24/25

Safety Statements ：: 28-36/37/39-45-28A

RIDADR ：: UN 2811 6.1/PG 3

WGK Germany ：: 3

RTECS ：: UP0740000

F ：: 13

Hazard Note ：: Irritant

HazardClass ：: 6.1

PackingGroup ：: III

HS Code ：: 29335990

Hazardous Substances Data：: 154-42-7(Hazardous Substances Data)

Toxicity：: LD50 oral in mouse: 160mg/kg

Use：: 6-Thioguanine is a purine analogue structurally related to 6-mercaptopurine and azathioprine. Thioguanine interferes with several enzymes required for de novo purine synthesis, and its metabolites are incorporated into DNA and RNA, further impeding nucleic acid synthesis. The mechanism of action of thioguanine in psoriasis is not clearly understood; it has been hypothesized to affect the proliferation and trafficking of lymphocytes as well as the proliferation of keratinocytes.

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Hebei Yanxi Chemical Co., Ltd.