(1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone suppliers

(1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone

CAS:: 128517-07-7

MF:: C24H36N4O6S2

MW:: 540.7

Use：: The U.S. FDA approved romidepsin (also referredto as FK228) in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) for patients who received at least one systemic therapy. Romidepsin is a natural product that was first isolated from the fermentation broth of C. violaceum. Romidepsin is the second histone deacetylase (HDAC) inhibitor approved for CTCL, the other being vorinostat,whichwas approved by the FDA in 2006. Unlike vorinostat which is a pan-HDAC inhibitor, romidepsin shows modest selectivity for class I HDACs in in vitro assays. It has been shown that after romidepsin enters the cytoplasm, the disulfide bond is cleaved by glutathione to release the sulfhydryl groupwhich chelateswith the activesite zinc of class IHDACs and inhibits the enzymatic activity at nanomolar concentrations. Although romidepsin inhibits class I HDACs, it is 17–23 times less potent as the parent than the corresponding reduced form at each isozyme. For example, the IC50 of romidepsin at HDAC1 is 36±16nM while that of the reduced form is IC50=1.6± 0.9nM.Romidepsinhasalsobeenshownto induce cell cycle arrest, differentiation, and apoptosis in tumor cells by mechanisms that cannot be completely explained by HDAC inhibition alone.Labelled Romidepsin (R425060). Romidepsin is a histone deacetylase inhibitor that can alter chromatin structure and gene transcription leading to multiple changes in cellular protein production. This may result in cell cycle arrest and tumor growth inhibition. Romidepsin has shown anti-proliferative activity in vitro against multiple mouse and human tumor cell lines and in vivo in human tumor xeno graft models. Romidepsin can be administered with a second agent, such as a cytotoxic agent, a steroidal agent, a proteasome inhibitor, or a kinase inhibitor.

More▼

You can find (1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone suppliers, manufacturers, and distributors from countries such as CHINA, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

career henan chemical co

(1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone
Remarks: Purity: 98% | Package: 1KG;1USD
TEL: 0371-86658258
CHINA Reagent

￥1.00/1KG

BOC Sciences

Romidepsin
Remarks: Purity: >98% | Package: 10 mg | CustNote: Reach out to us for more information about custom solutions.
UNITED STATES Trader

TargetMol Chemicals Inc.

Romidepsin
Remarks: Purity: 99.67% | Package: 1mg;98USD|2mg;154USD|5mg;249USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
TEL: +1-781-999-5354
UNITED STATES Trader

Dideu Industries Group Limited

(1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone
Remarks: Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
TEL: +86-29-89586680
CHINA Trader

Zhejiang J&C Biological Technology Co.,Limited

FK228 Romidepsin FK-228
Remarks: Purity: 99% | Package: 5KG;1KG | CustNote: FK228
TEL: 1-2135480471
CHINA Trader

CD Chemical Group Limited

(1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone
Remarks: Purity: 0.99 | Package: 1000KG;100KG;5KG;1KG
CHINA Trader

LEAP CHEM CO., LTD.

Depsipeptide
Remarks: Package: 1g; 5g; 25g; 1kg; 5kg; 25kg
TEL: 852-30606658
CHINA Trader

TargetMol Chemicals Inc.

Romidepsin；FK 228;Depsipeptide;NSC 630176;FR 901228
Remarks: Package: 1 mg；1 mL * 10mM (in DMSO)；10 mg；2 mg；5 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
TEL: +1-781-999-5354
UNITED STATES Reagent

GIHI CHEMICALS CO.,LIMITED

Romidepsin (FK228, Depsipeptide)
Remarks: Purity: 99 | Package: 5KG;1KG,25kg
TEL: 0571-86217390
CHINA Trader

SUZHOU SENFEIDA CHEMICAL CO.,LTD

Romidixin
Remarks: Purity: 99.9% | Package: 200kg
TEL: 0512-83500002
CHINA Manufacturer