1-Fluoropyridinium triflate

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H314：피부에 심한 화상과 눈에 손상을 일으킴

• 예방조치문구

  P260：분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P303+P361+P353：피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

  P363：다시 사용전 오염된 의류는 세척하시오.

1-Fluoropyridinium triflate 화학적 특성, 용도, 생산

• 화학적 성질

  white to off-white crystalline powder or needles

• 용도

  General purpose electrophilic fluorinating reagent.4

• Synthesis

  The round-bottomed reaction flask is charged with 4.74 g (0.06 mol) of pyridine, 10.3 g (0.06 mol) of sodium triflate, and 80 mL of dry acetonitrile. The system is purged with nitrogen, and the reaction mixture is chilled and maintained at ?40°C. The flow of dilute fluorine is started, and the flow rates from the nitrogen and fluorine cylinders are adjusted to introduce a 10% fluorine/90% nitrogen mixture at a rate of 90 mL/min just above the surface of the rapidly stirred solution. When a total of 2.7 L of fluorine (0.12 mol) is introduced, the flow of fluorine is discontinued, and nitrogen only flows through the system at a rate of 45 mL/min for 30 min while keeping the reaction mixture at ?40°C. The reaction mixture is then warmed to room temperature and filtered through a pad of Celite to remove the sodium fluoride. The filtrate is concentrated to dryness without heating with a rotary evaporator. The crystalline residue is washed with 30 mL of dry ethyl acetate to give 11.0–12.0 g (74–81%) of crude product, mp 178–181°C. The crude material is dissolved in 18 mL of dry acetonitrile at room temperature, and 36 mL of dry diethyl ether is added. The precipitated crystals are collected by filtration under nitrogen to give pure 1-Fluoropyridinium triflate.
  

1-Fluoropyridinium triflate 준비 용품 및 원자재

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