Fenbendazole

한글명:Fenbendazole

카스 번호43210-67-9

상품명:Fenbendazole

CBNumberCB9154575

분자식C15H13N3O2S

포뮬러 무게299.35

MOL 파일43210-67-9.mol

화학적 성질

녹는점	233°C
밀도	1.2767 (rough estimate)
굴절률	1.6740 (estimate)
저장 조건	2-8°C
수용성	물에 불용성
용해도	DMSO:16.67(Max Conc. mg/mL);55.69(Max Conc. mM) DMF:10.0(Max Conc. mg/mL);33.41(Max Conc. mM)
산도 계수 (pKa)	10.80±0.10(Predicted)
물리적 상태	Solid
색상	흰색에서 밝은 노란색
Merck	14,3960
BRN	759077
InChI	InChI=1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)
InChIKey	HDDSHPAODJUKPD-UHFFFAOYSA-N
SMILES	C(OC)(=O)NC1NC2=CC(SC3=CC=CC=C3)=CC=C2N=1
CAS 데이터베이스	43210-67-9(CAS DataBase Reference)
EPA	Carbamic acid, N-[6-(phenylthio)-1H-benzimidazol-2-yl]-, methyl ester (43210-67-9)

위험 및 안전 성명

위험품 표기	Xi
위험 카페고리 넘버	36/37/38
안전지침서	26-36-24/25
WGK 독일	2
RTECS 번호	DD6520500
HS 번호	29339900
독성	dog,LD50,oral,> 500mg/kg (500mg/kg),Pesticide Science. Vol. 8, Pg. 550, 1977.

그림문자(GHS)

Fenbendazole MSDS

Fenbendazole 화학적 특성, 용도, 생산

개요
Fenbendazole is a benzimidazole anthelmintic. It is active against Giardia in vitro (IC₅₀ = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection. Fenbendazole also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.
화학적 성질
Off-White Solid
용도
Fenbendazole is a benzimidazole anthelmintic that is metabolised in mammals to a series of other benzimidazoles including oxfendazole. It is used for the control of gastrointestinal roundworms, lung worms, Nematodes and tape worms. It is the only benzimidazole approved for use in organic livestock production.
용도
Fenbendazole is a medication used to treat parasites, mainly in dogs. However, studies have found that in a group of mice treated with a combination of fenbendazole and vitamins, tumor growth inhibition was unexpected It may be because it interferes with the uptake of glucose by cancer cells, which is essential for tumor growth and proliferation. It prevents cancer cells from obtaining the glucose needed to grow and divide to inhibit the growth of cancer cells. Studies have found that fenbendazole can kill cancer cells and promote tumor regression in patients with metastatic large B-cell lymphoma, and also plays a role in other metastatic malignant tumors such as bladder cancer and renal cell carcinoma. It is currently being treated in combination with other anti-cancer drugs to study its anti-cancer potential[1-3].
정의
ChEBI: Fenbendazole is a member of the class of benzimidazoles that is 1H-benzimidazole which is substituted at positons 2 and 5 by (methoxycarbonyl)amino and phenylsulfanediyl groups, respectively. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections. It has a role as an antinematodal drug. It is a member of benzimidazoles, a carbamate ester and an aryl sulfide.
일반 설명
Fenbendazole is a thio substituted benzimidazole, which belongs to the group of anthelmintics. It can be widely used in veterinary medicine particularly, in the treatment of helminth infections.
부작용
According to the results of toxicological studies, fenbendazole appears to be a safe drug, but up to 5% of people may experience stomach pain or diarrhea if taken in large amounts without interruption. People with severe renal failure or liver failure have a reduced level of drug excretion, and since fenbendazole powder is metabolized mainly in the liver, long-term heavy use can cause an asymptomatic increase in liver enzymes.
Mode of action
Fenbendazole is a benzimidazole antiparasitic drug that works at the sub-cellular level preventing cell division. Benzimidazoles bind to the β-tubulin, inhibiting the cell’s microtubule assembly responsible for intracellular transport and required for mitotic cellular division. In effect, it starves the parasite by causing intestinal cell disruption.

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