Mitiglinide calcium

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H413：장기적 영향에 의해 수생생물에 유해의 우려가 있음

• 예방조치문구

  P273：환경으로 배출하지 마시오.

  P501：...에 내용물 / 용기를 폐기 하시오.

Mitiglinide calcium 화학적 특성, 용도, 생산

• 용도

  Mitiglinide Calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells

• Mode of action

  Mitiglinide is another non-sulfonylurea insulin secretagogue. Insulin secretion is physiologically stimulated by the binding of ATP to a cytosolic nucleotide binding site of the membrane bound ATP-sensitive K+ channel which leads to closure of the K+ channel. The inhibition of K+ permeability depolarizes the plasma membrane, subsequently the voltage-dependent Ca2+ channel opens to promote the Ca2+ influx which finally results in insulin secretion. The insulin secretagogues stimulate insulin secretion by closure of this ATP-sensitive K+ channel of pancreatic -cells. KATP-channel consists of two subunits, a functional ion channel pore and a regulatory protein. The binding of the secretagogues is suggested to occur to the separate regulator protein containing the binding sites for sulfonylureas (sulfonylurea receptor 1, SUR1) but also other compounds.

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