L-(-)-루신

한글명:L-(-)-루신

카스 번호61-90-5

상품명:L-Leucine

CBNumberCB8742186

분자식C6H13NO2

포뮬러 무게131.17

MOL 파일61-90-5.mol

동의어(한글)

L-(-)-루신

L-루신

L-류신

화학적 성질

녹는점	>300 °C (lit.)
끓는 점	122-134 °C(Press: 2-3 Torr)
알파	15.4 º (c=4, 6N HCl)
밀도	1,293 g/cm³
증기압	<1 hPa (20 °C)
굴절률	1.4630 (estimate)
FEMA	3297 \| L-LEUCINE
인화점	145-148°C
저장 조건	2-8°C
용해도	1M HCl: 50mg/mL
물리적 상태	가루
산도 계수 (pKa)	2.328(at 25℃)
색상	흰색에서 황백색까지
수소이온지수(pH)	5.5-6.5 (20g/l, H2O, 20℃)
냄새	100.00%. 냄새 없는
optical activity	[α]20/D +15.5°, c = 2 in 6 M HCl
수용성	22.4g/L(20℃)
최대 파장(λmax)	λ: 260 nm Amax: 0.05 λ: 280 nm Amax: 0.05
JECFA Number	1423
Merck	14,5451
승화점	145-148 ºC
BRN	1721722
안정성	안정성 수분과 빛에 민감합니다. 강한 산화제와 호환되지 않습니다.
LogP	0.80
CAS 데이터베이스	61-90-5(CAS DataBase Reference)
NIST	Leucine(61-90-5)
EPA	L-Leucine (61-90-5)

위험 및 안전 성명

안전지침서

24/25

WGK 독일

RTECS 번호

OH2850000

TSCA

Yes

HS 번호

29224995

유해 물질 데이터

61-90-5(Hazardous Substances Data)

NFPA 704:

	1
1		1

그림문자(GHS)

L-(-)-루신 MSDS

L-(-)-루신 화학적 특성, 용도, 생산

순도시험

(1) 비선광도 : 이 품목 4g을 정밀히 달아 6N 염산을 가하여 녹인 다음 100mL로 하여 이 액의 선광도를 측정하고 다시 건조물로 환산할 때, ＝+14.5～+16.5°이어야 한다.
(2) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 5.0ppm 이하이어야 한다.
(3) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.
정량법

이 품목을 건조한 다음 약 0.4g을 정밀히 달아 개미산 3mL 및 빙초산 50mL를 가하여 녹인 다음 0.1N 과염소산용액으로 적정한다(지시약 : 크리스탈바이올렛․빙초산시액 2방울). 종말점은 액의 색이 청녹색으로 변하는 점이다. 따로 같은 방법으로 공시험을 한다.
0.1N 과염소산용액 1mL ＝ 13.12mg C₆H₁₃NO₂
강열잔류물

이 품목의 강열잔류물은 0.1% 이하이어야 한다.
개요
Small, white, lustrous plates, or a white, crystalline powder, with a slightly bitter taste. One g dissolves in about 40 mL of water and in about 100 mL of acetic acid. It is sparingly soluble in alcohol, but is soluble in dilute hydrochloric acid and in solutions of alkali hydroxides and carbonates. ι-Leucine may be synthesized by bromination, followed by amination of isocaproic acid; via the acetamidomalonic ester; by isolation from gluten, casein, keratin; from hydantoin.
화학적 성질
L-Leucine is odorless and has a slightly bitter taste. L-Leucine is a branched-chain, essential amino acid that stimulates muscle protein synthesis.
출처
Reported found as a constituent in proteins; also present in the free state in the human body
용도
L-Leucine plays a vital role in hemoglobin formation, protein synthesis and metabolic functions. It assists the growth and repair of muscle and bone tissue. It is used in the treatment of amyotrophic lateral sclerosis - Lou Gehrig's disease. It prevents the breakdown of muscle proteins after trauma or severe stress and may be beneficial for individuals with phenylketonuria. It is also used as a food additive and flavor enhancer. Further, it is used to preserve muscle glycogen.
제조 방법
By bromination followed by amination of isocaproic acid; via the acetamidomalonic ester; by isolation from gluten, casein, keratin; from hydantoin.
생산 방법
Leucine is produced microbially by incubating an amino-acidproducing microorganism including but not exclusive to Pseudomonas, Escherichia, Bacillus, or Staphylococcus in the presence of oxygen and a hydrocarbon. The nutrient medium should contain an inhibitory amount of a growth inhibitor that is a chemically similar derivative of leucine (e.g. methylallylglycine, a-hydrozinoisocaproic acid, or b-cyclopentanealanine) to inhibit the growth of the organism except for at least one mutant that is resistant to the inhibitory effect. The resistant mutant is then isolated and grown in the presence of oxygen and the hydrocarbon in the absence of the inhibitor. The mutant cells are then harvested and a nutrient medium is formed that includes a hydrocarbon as the sole source of carbon. Finally, the harvested cells are incubated in the medium in the presence of oxygen.
정의
ChEBI: The L-enantiomer of leucine.
Pharmaceutical Applications
Leucine is used in pharmaceutical formulations as a flavoring agent. It has been used experimentally as an antiadherent to improve the deagglomeration of disodium cromoglycate micro-particles and other compounds in inhalation preparations; and as a tablet lubricant. Leucine copolymers have been shown to successfully produce stable drug nanocrystals in water.
Safety
Leucine is an essential amino acid and is consumed as part of a normal diet. It is generally regarded as a nontoxic and nonirritant material. It is moderately toxic by the subcutaneous route.
LD50 (rat, IP): 5.379 g/kg
저장
Leucine is sensitive to light and moisture, and should be stored in an airtight container in a cool, dark, dry place.
Purification Methods
Likely impurities are isoleucine, valine, and methionine. Crystallise L-leucine from water by adding 4 volumes of EtOH. It sublimes at 180-188o/0.3mm with 99.1% recovery, and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2075-2094 1961, Kameda et al. J Pharm Soc Jpn 78 763 1958, Beilstein 4 IV 2738.]
비 호환성
Leucine is incompatible with strong oxidizing agents.
Regulatory Status
Included in the FDA Inactive Ingredients Database (IV infusion; oral tablets). Included in nonparenteral medicines licensed in the UK.

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