코바마마이드

한글명:코바마마이드

카스 번호13870-90-1

상품명:Coenzyme B12

CBNumberCB8433734

분자식C72H99CoN18O17P

포뮬러 무게1578.6

MOL 파일13870-90-1.mol

동의어(한글)

코바마마이드

화학적 성질

저장 조건	-20°C
용해도	DMSO(약간 용해됨), 메탄올(약간 용해됨), 물(약간 용해됨, 초음파 처리)
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	3.5(at 25℃)
색상	빨간색에서 매우 어두운 빨간색까지
수용성	26g/L(24℃)
Merck	13,2476
BRN	4122932
안정성	흡습성
InChIKey	WAJLPPDUWGAMTH-NGQUPMDYNA-L

위험 및 안전 성명

위험품 표기	Xi
위험 카페고리 넘버	36/37/38
안전지침서	22-24/25-36-26
WGK 독일	3
RTECS 번호	GG3800000
F 고인화성물질	8
HS 번호	2936260000
독성	LD50 oral in guinea pig: 5gm/kg

그림문자(GHS)

코바마마이드 화학적 특성, 용도, 생산

개요
Coenzyme B12 (adenosylcobalamin; AdoCbl; 5'-Deoxyadenosylcobalamin) is a form of vitamin B12. It belongs to the corrinoid group of compounds containing a corrin macrocycle and are produced only by certain bacteria and archaea. It is a cofactor for various enzymes, including mutases, eliminases, aminomutases, and reductases. These enzymes catalyze reactions that generate free radicals through the release of the adenosyl group, allowing usually unreactive molecules to become reactive. Genetic mutations in enzymes synthesizing Coenzyme B12 lead to Coenzyme B12 deficiency and methylmalonic aciduria.
용도
emulsifying agent
정의
ChEBI: A member of the class of cobalamins that is vitamin B12 in which the cyano group is replaced by a 5'-deoxyadenos-5'-yl moiety. It is one of the two metabolically active form of vitamin B12.
일반 설명
Vitamin B₁₂ cobalamin refers to a group of chemically-related cobalt containing molecules. The physiologically active forms of vitamin B₁₂ include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B_12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms.
농업용
Cobamide enzyme is the cobalt complex formed between the cobalt-porphyrin ring structure and the nucleotide in vitamin B₁₂co-enzyme.
참고 문헌
[1] Thuan Phu Nguyen-Vo. “Analysis and characterization of coenzyme B12 biosynthetic gene clusters and improvement of B12 biosynthesis in Pseudomonas denitrificans ATCC 13867.” Fems Microbiology Letters 365 21 (2018).
[2] I. I. Merkelbach, Hm Henk Buck. “Mechanism of action of coenzyme B12. Quantum-chemical considerations.” Recueil des Travaux Chimiques des Pays-Bas 28 1 (2010): 166–169.
[3] Prof. Dr. Karl Gruber, Prof. Dr. Bernhard Krutler. “Coenzyme B12 Repurposed for Photoregulation of Gene Expression.” Angewandte Chemie International Edition 55 19 (2016): 5638–5640.

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