토코페솔란

한글명:토코페솔란

카스 번호9002-96-4

상품명:Tocofersolan

CBNumberCB8396198

분자식(C2H4O)nC33H54O5

포뮬러 무게0

MOL 파일9002-96-4.mol

동의어(한글)

토코페솔란

비타민E폴리에틸렌글리콜숙시네이트(TPGS)

화학적 성질

녹는점	34-38°C
저장 조건	2-8°C
용해도	H2O: 가용성 1g/10mL, 투명하거나 희미한 혼탁함, 무색 내지 희미한 노란색
물리적 상태	고체
물리적 상태	단단한 모양
색상	흰색에서 연한 노란색 왁스
InChI	InChI=1S/C34H56O6/c1-23(2)12-9-13-24(3)14-10-15-25(4)16-11-20-34(8)21-19-29-28(7)32(26(5)27(6)33(29)40-34)39-31(37)18-17-30(36)38-22-35/h23-25,35H,9-22H2,1-8H3
InChIKey	WFWQYXBTWIHIIW-UHFFFAOYSA-N
SMILES	C(=O)(OC1C(C)=C2CCC(C)(CCCC(CCCC(CCCC(C)C)C)C)OC2=C(C)C=1C)CCC(=O)OCO
LogP	9.745 (est)

위험 및 안전 성명

WGK 독일

RTECS 번호

TR1581200

HS 번호

2936.28.0000

NFPA 704:

	1
0		0

토코페솔란 MSDS

토코페솔란 화학적 특성, 용도, 생산

화학적 성질
Vitamin E polyethylene glycol succinate is a synthetic product. It is available as a white to light-brown, waxy solid and is practically tasteless. Chemically, it is a mixture composed principally of monoesterified polyethylene glycol 1000, the diesterified polyethylene glycol 1000, free polyethylene glycol 1000, and free tocopherol.
생산 방법
Vitamin E polyethylene glycol succinate is prepared by esterification of the acid group of crystalline D-a-tocopheryl acid succinate by polyethylene glycol 1000.
Pharmaceutical Applications
Vitamin E polyethylene glycol succinate is an esterified vitamin E (tocopherol) derivative primarily used as a solubilizer or emulsifying agent because of its surfactant properties. Structurally, it is amphipathic and hydrophilic, unlike the tocopherols, and therefore it is a water-soluble derivative that can be used in pharmaceutical formulations such as capsules, tablets, hot-melt extrusion, microemulsions, topical products, and parenterals. One of the most important applications is its use as a vehicle for lipid-based drug delivery formulations. It can also be used as a source of vitamin E.
Vitamin E polyethylene glycol succinate has been characterized with respect to its mechanism of action and studied as a Pglycoprotein inhibitor.
Safety
Vitamin E polyethylene glycol succinate has been used at levels of 280 mg/capsule in the product Agenerase (amprenavir), which was dosed at 8 capsules (2240mg vitamin E TPGS) per day. An additional assessment of the safety of vitamin E polyethylene glycol succinate has been published, which includes a report showing no-observed-adverse-effect-level (NOAEL) in rats of 1000 mg/kg/day.
저장
Vitamin E polyethylene glycol succinate is stable at ambient room temperature for up to 4 years. It reacts with alkalis and acids. Aqueous solutions of vitamin E polyethylene glycol succinate are stable over a pH range of 4.5–7.5 and can be further stabilized with propylene glycol.
비 호환성
Vitamin E polyethylene glycol succinate is incompatible with strong acids and strong alkalis.
Regulatory Status
GRAS listed. Included in the FDA Inactive Ingredients Database (ophthalmic solution or drops; oral capsules, solution, tablet; topical solution or drops). Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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