융모성성선자극호르몬

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H361：태아 또는 생식능력에 손상을 일으킬 것으로 의심됨

• 예방조치문구

  P281：요구되는 개인 보호구를 착용하시오

융모성성선자극호르몬 화학적 특성, 용도, 생산

• 화학적 성질

  White or yellowish-white, amorphous powder.

• 용도

  Chorionic gonadotropin human has been used:
  
  • to induce oocyte maturation in cultured follicles
  • along with pregnant mare serum gonadotropin (PMSG) to induce superovulation in mice
  • as medium component for fetal testes culture to aid steroidogenic responsiveness
  
  

• 생산 방법

  CG is produced in the chorion.

• 주요 응용

  Human chorionic gonadotropin (hCG) is a chemical produced by the trophoblast tissue, which is usually present in the early embryo and will eventually become part of the placenta. Measuring hCG levels helps to identify normal, pathological and miscarried pregnancies. Measuring hCG is also beneficial for many cancers including choriocarcinoma and extrauterine malignancies.

• 일반 설명

  Glycoprotein hormone consisting of a 92-amino acid α-chain which is identical to that of LH, FSH, and TSH; and a distinct 149-amino acid β-chain. Produced by chorionic tissue and responsible for maintaining the corpus luteum during early pregnancy. Also produced by trophoblast cell neoplasms, which are marked by elevated free hCG β-chains and hyperglycosylated hCG.

• Clinical Use

  Choriogonadotropin alfa is obtained by rDNA technology and is biologically and chemically identical to hCG of natural origin. It is used, like hCG of natural origin, for inducing ovulation in women with anovulatory infertility. Following proper pretreatment with a GnRH antagonist or superagonist to desensitize the pituitary, women participating in ART are treated with a folliclestimulating agent (e.g., menotropins) to effect the final maturation of the follicles within the ovaries. Ultrasonograms are used to determine proper follicle maturation before the administration of choriogonadotropin alfa to induce ovulation. A distinct advantage of this product is that it can be self-administered by the patient via SC injection.

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