인산트리크레질

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• 그림문자(GHS)

  

• 신호 어

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• 유해·위험 문구

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• 예방조치문구

  P201：사용 전 취급 설명서를 확보하시오.

  P202：모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.

  P273：환경으로 배출하지 마시오.

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  P391：누출물을 모으시오.

인산트리크레질 MSDS

• Tritolyl phosphate

인산트리크레질 화학적 특성, 용도, 생산

• 개요

  Tricresyl Phosphate (TCP) is a mixture with a slightly pungent odor: of the three isomers, the normal and meta isomers are liquids, while the para isomer is a crystalline solid. TCP can be obtained by treating cresol with phosphorus oxychloride in the presence of an aluminum catalyst. It is used to recover phenol residues in gas plant wastewater and is also used as a plasticizer in the plastics industry. Plasticizers are substances used to increase the flexibility of plastic materials. By changing the amount of plasticizer added, the flexibility, hardness, water resistance and flammability of plastic materials can be changed over a wide range. Sometimes up to 50% TCP is added to polyvinyl chloride^[1]. In addition, TCP is toxic to humans and can cause neuropathy, paralysis of the hands and feet, and/or death of humans and animals through ingestion, inhalation, and even absorption through the skin.
  

• 화학적 성질

  Tricresyl phosphate is an isomeric mixture of phosphoric acid esters of cresols. It is an odourless and colourless oily liquid (molar mass 368.4 g/mol, melting point –33°C).
  
  Tricresyl phosphates were used as flame retardants and plasticisers in PVC, nitrocellulose and acrylates.

• 용도

  Tricresyl phosphate (TCP) is used as a solvent for nitrocellulose esters and numerous natural resins. It is a plasticizer for chlorinated rubber, vinyl plastics, polystyrene and polyacrylic and polymethacrylic esters. Tricresyl phosphate also acts as a binder for resins and nitrocellulose to improve toughness, elasticity and polishing properties of coatings. Alone or associated with hydrocarbons, it is used as an antiwear and antifriction additive in numerous synthetic lubricants, incorrectly termed “oils” by reason of their appearance. It is also employed as a hydraulic fluid. When incorporated in gasoline, tricresyl phosphate counteracts the harmful effects of lead deposits. In addition, it is an excellent fire retardant in many industries.
  Usually used as a mediator in the preparation of uranium-sensitive electrode based on membrane containing uranium di-(4-octylphenyl)phosphate as sensor.

• 제조 방법

  Tricresyl phosphate is prepared by reaction of cresols with phosphorus oxychloride, phosphoric acid, or phosphorus pentachloride:
  OPCl3 + 3 HOC6H4CH3 → OP(OC6H4CH3)3 + 3 HCl
  The grades of cresol commonly is a mixture of three isomers (o-, m-, p-). The fact that tricresyl phosphate is derived from a mixture and itself is a mixture ensures that it remains liquid over a wide span of temperatures.
  A "refined grade" of tricresyl phosphate is prepared by vacuum distillation, or alternatively by washing with 2% sodium hydroxide and water.

• 건강위험

  The tricresyl phosphates (TCPs) are part of a series of organophosphorus compounds which have been shown to cause delayed neurotoxicity. The 1930 outbreak of “ginger jake” paralysis was caused by the contamination of ginger extract by cresyl phosphates, used in the processing of the spice. Since that time, there have been several incidents reported of accidental poisoning of food by tri-o-cresyl phosphate (TOCP). There are few case series reports of occupational exposure in the literature. Acute occupational exposures have been described as causing gastrointestinal symptoms followed by a latent period of days to 4 weeks, after which extremity pain and tingling progress to motor paralysis of the lower extremities up to the thighs, and of the upper extremities to the elbow. There is rarely sensory loss. Partial to total recovery may take years. Fatalities have occurred in high-dose ingestion.

• Safety Profile

  Moderately toxic by ingestion and skin contact. Human systemic effects by ingestion: flaccid paralysis without anesthesia, motor activity changes, and muscle weakness. An experimental teratogen. Experimental reproductive effects. An eye and skin irritant. Combustible. When heated to decomposition it emits toxic fumes of POx.

• 잠재적 노출

  According to the World Health Organization there is no safe level of exposure to Tricresyl Phosphate(TCP).
  TCP has been used as a flame retardant in fabric, plastics and rubbers and as a plasticizer in PVC, lacquers, varnishes and nitrocellulose. It is also used as a heat exchange medium and hydraulic fluid. TCP was detected in all house dust samples gathered in two different North American studies.Biomonitoring studies detected TCP in the breast milk of women in Asia and Sweden. EPA has characterized TCP to exhibit moderate persistence in the environment based on biodegradation studies.

• Purification Methods

  Dry the ester with CaCl2, percolate it through a column of alumina, then distil it under a vacuum. Alernatively pass it through a packed column of alumina at 150o, with a counter-current stream of nitrogen, under reduced pressure, to remove residual traces of volatile impurities. It also crystallises from pet ether (b 60-80o). [Cherbuliez in Organic Phosphorus Compounds (Kosolapoff & Maier eds) Wiley-Interscience Vol 6 pp 454-457 1973.]

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