타라칸트검

타라칸트검 MSDS

• Tragacanth gum

타라칸트검 화학적 특성, 용도, 생산

• 순도시험

    (1) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.

    (2) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.

    (3) 카드뮴 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 1.0ppm 이하이어야 한다.

    (4) 수은 : 이 품목 0.1g을 취하여 수은시험법에 따라 시험할 때, 그 양은 1.0ppm 이하이어야 한다.

    (5) 대장균 : 이 품목은 「식품의 기준 및 규격」 일반시험법의 미생물시험법 중 대장균에 따라 시험할 때, 음성(-)이어야 한다.

    (6) 살모넬라 : 이 품목은 「식품의 기준 및 규격」 일반시험법의 미생물시험법 중 살모넬라에 따라 시험할 때, 음성(-)이어야 한다.

    (7) 카라야검 : 이 품목 1g에 물 20mL를 가하여 균일한 점조액이 될 때까지 가열하고 이에 염산 5mL를 가해주고 5분간 가열할 때, 액은 엷은 홍～적색을 나타내서는 아니 된다.

    (8) 점도 : 이 품목의 미세한 분말 4.0g을 교반용기에 넣고 에탄올 10mL를 가해주고 균일하게 적신 다음 물 390mL를 가해 준다. 이 때 덩어리가 생기지 않도록 주의하면서 이 액을 7분간 교반시키고 나서 500mL의 병에 옮겨 마개를 한 후 25℃의 수욕에서 24시간 정치한 액을 시험용액으로 하여 점도측정법 중 제2법 회전식점도측정법에 따라 시험할 때, 250cps 이상이어야 한다.

    (9) 산불용물회분 : 회분시험법 중 산불용성회분에 따라 시험할 때, 그 양은 0.5% 이하이어야 한다.

• 확인시험

    (1) 이 품목 1g에 물 50mL를 가할 때 거의 균일하게 점차 현탁한 액이 된다.

    (2) 이 품목의 분말에 요오드시액을 가해주고 현미경으로 관찰할 때 청색을 나타내는 전분알갱이 약간의 수를 확인할 수 있다.

• 정의

    이 품목은 콩과 Astragalus gummifer LABILL. 또는 동종식물의 줄기에서 침출한 분비물을 건조하여 얻어지는 다당류이다.

• 화학적 성질

  Tragacanth gum occurs as flattened, lamellated, frequently curved fragments, or as straight or spirally twisted linear pieces from 0.5–2.5mm in thickness; it may also be obtained in a powdered form. White to yellowish in color, tragacanth is a translucent, odorless substance, with an insipid mucilaginous taste.

• 물리적 성질

  As collected, tragacanth is white to weak yellow, translucent; horny in texture, having a short fracture. It is rendered more easily pulverizable if heated to 50°C. Powdered tragacanth is white to yellowish white. Gum tragacanth swells in cold water to give extremely viscous colloidal solutions, probably the most viscous of all the plant gums.

• 용도

  tragacanth gum is an effective emulsifying agent, binder, film former, and viscosity controller, it is also used as a stabilizing ingredient in lotions. Tragacanth gum is derived from the resin of the Astragalus gummifer shrub.

• 생산 방법

  Tragacanth gum is the air-dried gum obtained from Astragalus gummifer Labillardie`re and other species of Astragalus grown principally in Iran, Syria, and Turkey. A low-quality gum is obtained by collecting the natural air-dried exudate from Astragalus bushes. A higher-grade material is obtained by making incisions in the trunk and branches of the bush, which are held open with variously sized wooden pegs. The exudate is left to drain from the incision and dry naturally in the air before being collected. The size and position of the wooden wedges determine the physical form of the exudate, while the drying conditions determine the color of the gum. After collection, the tragacanth gum is sorted by hand into various grades, such as ribbons or flakes.

• 일반 설명

  Tragacanth is a gum commonly found in the sap of various Middle Eastern legumes. It is commonly used as freezing-embedding medium for tissue preservation.

• Pharmaceutical Applications

  Tragacanth gum is used as an emulsifying and suspending agent in a variety of pharmaceutical formulations. It is used in creams, gels, and emulsions at various concentrations according to the application of the formulation and the grade of gum used.
  Tragacanth gum is also used similarly in cosmetics and food products, and has been used as a diluent in tablet formulations.

• Safety Profile

  Mildly toxic by ingestion. A mild allergen. A skin and eye irritant. Combustible when exposed to heat or flame. When heated to decomposition it emits acrid smoke and irritating fumes.

• Safety

  Tragacanth has been used for many years in oral pharmaceutical formulations and food products, and is generally regarded as an essentially nontoxic material. Tragacanth has been shown to be noncarcinogenic. However, hypersensitivity reactions, which are occasionaly severe, have been reported following ingestion of products containing tragacanth. Contact dermatitis has also been reported following the topical use of tragacanth formulations.
  The WHO has not specified an acceptable daily intake for tragacanth gum, as the daily intake necessary to achieve a desired effect, and its background levels in food, were not considered to be a hazard to health.
  LD50 (hamster, oral): 8.8 g/kg
  LD50 (mouse, oral): 10 g/kg
  LD50 (rabbit, oral): 7.2 g/kg
  LD50 (rat, oral): 16.4 g/kg

• 저장

  Both the flaked and powdered forms of tragacanth are stable. Tragacanth gels are liable to exhibit microbial contamination with enterobacterial species, and stock solutions should therefore contain suitable antimicrobial preservatives. In emulsions, glycerin or propylene glycol are used as preservatives; in gel formulations, tragacanth is usually preserved with either 0.1% w/v benzoic acid or sodium benzoate. A combination of 0.17% w/v methylparaben and 0.03% w/v propylparaben is also an effective preservative for tragacanth gels. Gels may be sterilized by autoclaving. Sterilization by gamma irradiation causes a marked reduction in the viscosity of tragacanth dispersions.
  Tragacanth dispersions are most stable at pH 4–8, although stability is satisfactory at higher pH or as low as pH 2. The bulk material should be stored in an airtight container in a cool, dry place.

• 비 호환성

  At pH 7, tragacanth has been reported to considerably reduce the efficacy of the antimicrobial preservatives benzalkonium chloride, chlorobutanol, and methylparaben, and to a lesser extent that of phenol and phenylmercuric acetate. However, at pH < 5 tragacanth was reported to have no adverse effects on the preservative efficacy of benzoic acid, chlorobutanol, or methylparaben.
  The addition of strong mineral and organic acids can reduce the viscosity of tragacanth dispersions. Viscosity may also be reduced by the addition of alkali or sodium chloride, particularly if the dispersion is heated. Tragacanth is compatible with relatively high salt concentrations and most other natural and synthetic suspending agents such as acacia, carboxymethylcellulose, starch, and sucrose. Ayellow colored, stringy, precipitate is formed with 10% w/v ferric chloride solution.

• Regulatory Status

  GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (buccal/ sublingual tablets, oral powders, suspensions, syrups, and tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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