Agmatine sulfate

한글명:Agmatine sulfate

카스 번호2482-00-0

상품명:Agmatine sulfate

CBNumberCB7421831

분자식C5H16N4O4S

포뮬러 무게228.27

MOL 파일2482-00-0.mol

화학적 성질

녹는점	234-238 °C(lit.)
RTECS 번호	ME8413000
저장 조건	Keep in dark place,Inert atmosphere,Room temperature
용해도	H₂O: 50 mg/mL
물리적 상태	가루
색상	흰색에서 황백색까지
수용성	물에 용해되고 알코올에는 거의 녹지 않음
Merck	14,188
BRN	3918807
InChI	InChI=1S/C5H14N4.H2O4S/c6-3-1-2-4-9-5(7)8;1-5(2,3)4/h1-4,6H2,(H4,7,8,9);(H2,1,2,3,4)
InChIKey	PTAYFGHRDOMJGC-UHFFFAOYSA-N
SMILES	C(CCCN)NC(N)=N.S(O)(O)(=O)=O
CAS 데이터베이스	2482-00-0(CAS DataBase Reference)

위험 및 안전 성명

안전지침서

22-24/25

WGK 독일

F 고인화성물질

HS 번호

29252900

NFPA 704:

	1
0		0

그림문자(GHS)

Agmatine sulfate MSDS

Agmatine sulfate 화학적 특성, 용도, 생산

개요
Agmatine sulfate is the sulfate of the Agmatine. Agmatine is an aninoguanidine that is naturally derived from the arginine. It can exert modulatory effect on many molecular targets such as neurotransmitter systems, opioid analgesia, ion channels, and nitric oxide (NO) synthesis and polyamine metabolism. It has been also found that it can reverse the pain induced from inflammation, neuropathy, and spinal cord injury. Those effects make it a potential candidate for multiple pharmacological applications in the future.
화학적 성질
White to off-white powder
용도
Agmatine Sulfate is a a polyamine derived from L-arginine (A769500) decarboxylation and is a known putative endogenous neurotransmitter at imidazoline receptors. Agmatine sulfate displaces clonidine a t α2-adrenergic and at imidazoline receptors and was recently shown to exert some neuroprotective effects.
생물학적 활성
Arginine metabolite that is synthesized within bovine brain and exhibits clonidine-displacing substance (CDS) activity. Putative endogenous ligand for the imidazoline binding site.
Purification Methods
Crystallise the salt from aqueous MeOH. The free base has m 101.5-103o, the gold chloride hydrochloride crystallises from H2O with m 223o(dec), and the picrate has m 236-238o. [Odo J Chem Soc Jpn 67 132 1946, Beilstein 4 I 420, 4 II 703, 4 III 575, 4 IV 1291.]
참고 문헌
Fairbanks, C. A., et al. "Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury." Proceedings of the National Academy of Sciences of the United States of America97.19(2000):10584.
Kolesnikov, Yuri, S. Jain, and G. W. Pasternak. "Modulation of opioid analgesia by agmatine." European Journal of Pharmacology296.1(1996):17-22.
Su, R. B., J. Li, and B. Y. Qin. "A biphasic opioid function modulator: agmatine. "Acta Pharmacologica Sinica24.7(2003):631.
Galea, Elena, et al. "Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine." Biochemical Journal 316 ( Pt 1).1(1996):247.
https://en.wikipedia.org/wiki/Agmatine

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