Thiopental Sodium

한글명:Thiopental Sodium

카스 번호71-73-8

상품명:Thiopental Sodium

CBNumberCB7106914

분자식C11H17N2NaO2S

포뮬러 무게264.32

MOL 파일71-73-8.mol

화학적 성질

용해도	H₂O: >10 mg/mL
색상	황색을 띠는 흡습성 분말
EPA	Thiopental sodium (71-73-8)

위험 및 안전 성명

위험품 표기	T
위험 카페고리 넘버	25
안전지침서	36-45
유엔번호(UN No.)	UN 2811 6.1/PG 3
WGK 독일	3
RTECS 번호	CQ6475000
위험 등급	6.1(b)
포장분류	III
독성	LD50 in mice (mg/kg): 149 i.p.; 78 i.v. (Christensen, Lee)

그림문자(GHS)

Thiopental Sodium 화학적 특성, 용도, 생산

화학적 성질
Yellowish-white, hygroscopic powder.
용도
Pentothal (Abbott).
정의
A rapidly acting barbiturate administered intravenously for general anesthesia and hypnosis. Commonly known as “truth serum.”
위험도
May cause respiratory failure; use onlywith physician in attendance.
Pharmacokinetics
Thiopental is highly bound to albumin, and free drug availability is increased in hypoproteinaemia. Protein binding is decreased by alkalaemia, hyperventilation and some drugs that occupy the same albumin binding sites, thereby increasing unbound thiopental concentrations. Metabolism occurs predominantly in the liver, and the metabolites are excreted by the kidneys. Only a small proportion is excreted unchanged in the urine. The terminal elimination half-life is approximately 11.5h (longer in the elderly). Elimination after an infusion is a zero-order process with 10%–15% of the remaining drug metabolised each hour. Up to 30% of the original dose may remain in the body at 24h, and a hangover effect is common. Accumulation may result if further doses of thiopental are administered within 1–2 days.
Safety Profile
Poison by ingestion, intraperitoneal, rectal, subcutaneous, and intravenous routes. Human systemic effects by intraarterial route: acute arterial occlusion; by rectal route: respiratory depression, body temperature decrease, general anesthetic. An experimental teratogen. Experimental reproductive effects. An intravenous anesthetic. When heated to decomposition it emits toxic fumes of NO, and Na2O. See also PENTOTHAL and BARBITURATES

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