MECLOFENAMATE SODIUM

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

• 예방조치문구

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

MECLOFENAMATE SODIUM 화학적 특성, 용도, 생산

• 개요

  Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC₅₀ values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 μM, respectively for instantaneous inhibition. However, the IC₅₀ is much lower if pre-incubated with the enzyme.

• 용도

  Meclofenamate Sodium is an NSAID used in the treatment of chronic pain.

• 정의

  ChEBI: An organic sodium salt derived from meclofenamic acid. Its monohydrate is used for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.

• Indications

  Meclofenamate sodium (Meclomen) is prescribed for rheumatoid arthritis and osteoarthritis. The fenamates show no clear superiority in antiinflammatory activity and may produce more adverse effects than other NSAIDs.

• 일반 설명

  Meclofenamate sodium (Meclomen) is available for use inthe treatment of acute and chronic RA, OA, and primarydysmenorrhea. It is metabolized in a similar manner tomefenamic acid discussed above, thus a similar restriction isalso applied to meclofenamate. The most significant side effectsare GI, including diarrhea.

• Pharmacokinetics

  Meclofenamate sodium is rapidly and almost completely absorbed following oral administration, reaching peak plasma levels within 2 hours. It is highly bound to plasma proteins (99%) and has a plasma half-life of 2 to 4 hours. Metabolism involves oxidation of the methyl group, aromatic hydroxylation, monodehalogenation, and conjugation. Urinary excretion accounts for approximately 75% of the administered dose. The major metabolite is the product of 3′-methyl oxidation and has been shown to possess anti-inflammatory activity.
  

• Clinical Use

  Meclofenamate sodium is indicated for the relief of mild to moderate pain, the acute and chronic treatment of rheumatoid arthritis and osteoarthritis, the treatment of primary dysmenorrhea, and the treatment of idiopathic, heavy menstrual blood loss.

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