프레드니손

한글명:프레드니손

카스 번호53-03-2

상품명:Prednisone

CBNumberCB6716222

분자식C21H26O5

포뮬러 무게358.43

MOL 파일53-03-2.mol

동의어(한글)

프레드니손

화학적 성질

녹는점	236-238 °C(lit.)
알파	169 º (c=0.5, dioxane)
끓는 점	410.86°C (rough estimate)
밀도	1.1121 (rough estimate)
굴절률	170 ° (C=0.5, Dioxane)
인화점	>200℃
저장 조건	2-8°C
용해도	물에는 거의 녹지 않으며, 에탄올(96%)과 염화메틸렌에는 약간 녹습니다. 다형성(5.9)을 보여줍니다.
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	12.36±0.60(Predicted)
색상	흰색에서 황백색까지
수용성	115mg/L(25℃)
Merck	7722
BRN	2065301
BCS Class	1?
안정성	안정적인. 강한 산화제와 호환되지 않습니다.
CAS 데이터베이스	53-03-2(CAS DataBase Reference)
IARC	3 (Vol. 26, Sup 7) 1987
NIST	Prednisone(53-03-2)
EPA	Prednisone (53-03-2)

위험 및 안전 성명

위험품 표기	Xn
안전지침서	36/37/39-45-26-16
유해 물질 데이터	53-03-2(Hazardous Substances Data)

그림문자(GHS)

프레드니손 MSDS

프레드니손 화학적 특성, 용도, 생산

화학적 성질
White or almost white, crystalline powder.
용도
Prednisone is used for the same indications as cortisone for inflammatory processes, allergies, and adrenal gland insufficiency; however, it is somewhat more active than cortisone and has less of an effect on mineral volume.
정의
ChEBI: A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead f the oxo group at position 11), which is the active drug and also a steroid.
Indications
Prednisone 2.5 to 7.5 mg, administered at night or dexamethasone 0.25 to 0.75 mg are useful in female patients, with severe acne unresponsive to conventional therapy, who suffer from adrenal gland overproduction of androgens such as congenital adrenal hyperplasia.
일반 설명
Prednisone, Δ¹-cortisone, 17,21-dihydroxypregna-1,4-diene-3,11,20-trione, has systemic activityvery similar to that of prednisolone, and because of itslower salt-retention activity, it is often preferred over cortisoneor hydrocortisone. Prednisone must be reduced in vivoto prednisolone to provide the active GC.
공기와 물의 반응
Very slightly water soluble .
위험도
Questionable carcinogen.
Safety Profile
Poison by intraperitoneal and subcutaneous routes. Moderately toxic by intramuscular route. Human systemic effects: sensory change involving peripheral nerves, dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Has been implicated in aplastic anemia.
Purification Methods
Crystallise prednisone from acetone/hexane, then recrystallise it from Me2CO. The monoacetate crystallises from Me2CO/hexane with m 227-233o(dec), [] D +186o (c 1, dioxane), and the diacetate crystallises from 25Me2CO/hexane with m 219-221o(dec), [] D +125o (c 1, CHCl3). [Hertzog et al. Tetrahedron 18 581 1962, Beilstein 8 IV 3531.]

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