CYCLOPENTOLATE HYDROCHLORIDE

한글명:CYCLOPENTOLATE HYDROCHLORIDE

카스 번호5870-29-1

상품명:CYCLOPENTOLATE HYDROCHLORIDE

CBNumberCB6287038

분자식C17H26ClNO3

포뮬러 무게327.85

MOL 파일5870-29-1.mol

화학적 성질

녹는점	137-141°
저장 조건	Inert atmosphere,Room Temperature
용해도	물에 매우 잘 녹고 에탄올에 잘 녹습니다(96%). 다형성(5.9)을 보여줍니다.
물리적 상태	Solid
색상	흰색에서 황백색까지

위험 및 안전 성명

WGK 독일

RTECS 번호

GY2450000

HS 번호

2922190900

NFPA 704:

	0
2		0

그림문자(GHS)

CYCLOPENTOLATE HYDROCHLORIDE 화학적 특성, 용도, 생산

개요
Cyclopentolate is an antagonist of muscarinic acetylcholine receptors (K_is = 1.62, 27.5, and 2.63 nM for M₁, M₂, and M₃ receptors, respectively). It inhibits carbachol-induced contraction of isolated human iris sphincter, circular ciliary muscle, and longitudinal ciliary muscle (K_bs = 7.9, 15.8, and 12.5 nM, respectively). Formulations containing cyclopentolate have been used to induce pupil dilation and to prevent the eye from accommodating for near vision.
화학적 성질
White Solid
용도
Mydriatic;Cholinergic receptor antagonist
일반 설명
Cyclopentolatehydrochloride, 2-dimethylaminoethyl 1-hydroxy- -phenylcyclopentaneacetatehydrochloride (Cyclogyl), is a crystalline,white, odorless solid that is very soluble in water,easily soluble in alcohol, and only slightly soluble in ether.A 1% solution has a pH of 5.0 to 5.4.
Cyclopentolate hydrochloride has one half of the antispasmodicactivity of atropine and is nonirritating when instilledrepeatedly into the eye. If not neutralized after the refractionstudies, its effect dissipates within 24 hours. Neutralizationwith a few drops of pilocarpine nitrate solution, 1% to 2%,often results in complete recovery in 6 hours. It is supplied asa ready-made ophthalmic solution in concentrations of either0.5% or 2%.
Clinical Use
Cyclopentolate Hydrochloride is used only for its effects on the eye, where it acts asa parasympatholytic. When placed in the eye, it quickly producescycloplegia and mydriasis. Its primary field of usefulnessis in refraction studies. Cyclopentolate hydrochloridecan be used, however, as a mydriatic in the management ofiritis, iridocyclitis, keratitis, and choroiditis. Although itdoes not seem to affect intraocular tension significantly, it isbest to be very cautious with patients with high intraocularpressure and with elderly patients with possible unrecognizedglaucomatous changes.

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