5,6,7,8-테트라하이드로-1,7-나프티리딘염산염

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

5,6,7,8-테트라하이드로-1,7-나프티리딘염산염 화학적 특성, 용도, 생산

• 용도

  5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

• Synthesis

  
  5,6,7,8-Tetrahydro-[1,7]napthyridine hydrochloride. A methanolic solution (25 mL) of 7-Benzyl-5,6,7,8-tetrahydro-[1,7]naphthyridine (J. Het. Chem. 2001, 38, 535) (1.5g, 6.69 mmol) was degassed with argon for 20 min followed by the addition of 4N HCl in dioxane (2 mL) and Pd/C (300 mg, 20 wt%) and stirred under 50 psi hydrogen pressure at room temperature for 24h. After completion of the reaction the mixture was filtered on a short pad of celite and washed with methanol (4 × 25 mL). The filtrate was evaporated to dryness in vacuo and crystallized from methanol. Yield: 65% (calculated as 2HCl salt), 900 mg, yellowish solid.

5,6,7,8-테트라하이드로-1,7-나프티리딘염산염 공급 업체

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