4-클로로-m-크레졸

한글명:4-클로로-m-크레졸

카스 번호59-50-7

상품명:4-Chloro-3-methylphenol

CBNumberCB5703115

분자식C7H7ClO

포뮬러 무게142.58

MOL 파일59-50-7.mol

동의어(한글)

4-클로로-m-크레졸

p-클로로-m-크레졸

4-클로로-3-메틸페놀

화학적 성질

녹는점	63-65 °C (lit.)
끓는 점	235 °C (lit.)
밀도	1.370
벌크 밀도	800kg/m3
증기압	<0.1 hPa (20 °C)
굴절률	1.5449 (estimate)
인화점	118 °C
저장 조건	Store below +30°C.
용해도	메탄올: 용해성1g/10mL, 투명, 무색
물리적 상태	플레이크 크리스탈
산도 계수 (pKa)	pKa 9.55(t = 25) (Uncertain)
색상	하얀색
수소이온지수(pH)	6.5 (1g/l, H2O, 20℃)
수용성	4g/L(20℃)
Merck	14,2133
BRN	1237629
Henry's Law Constant	2.5(x 10^-6 atm?m³/mol)at 20 °C (calculated, Mabey et al., 1982)
안정성	안정적인. 황동, 산화제, 구리, 구리 합금과 호환되지 않습니다.
InChIKey	CFKMVGJGLGKFKI-UHFFFAOYSA-N
LogP	3.100
CAS 데이터베이스	59-50-7(CAS DataBase Reference)
NIST	Phenol, 4-chloro-3-methyl-(59-50-7)
EPA	p-Chloro-m-cresol (59-50-7)

위험 및 안전 성명

위험품 표기

Xn,N,T,F

위험 카페고리 넘버

21/22-41-43-50-39/23/24/25-23/24/25-11-38

안전지침서

26-36/37/39-61-45-36/37-16-7-28

유엔번호(UN No.)

UN 3077 9/PG 3

WGK 독일

RTECS 번호

GO7100000

자연 발화 온도

590 °C

TSCA

Yes

위험 등급

6.1(a)

포장분류

HS 번호

29081000

유해 물질 데이터

59-50-7(Hazardous Substances Data)

독성

LD50 orally in Rabbit: 1830 mg/kg LD50 dermal Rat > 2000 mg/kg

NFPA 704:

	1
3		0

그림문자(GHS)

4-클로로-m-크레졸 MSDS

4-클로로-m-크레졸 화학적 특성, 용도, 생산

화학적 성질
white or pink crystals
물리적 성질
Colorless, white, or pinkish crystals with a slight phenolic odor. On exposure to air it slowly becomes light brown.
용도
4-Chloro-3-methylphenol has been used in paint formulations.
생산 방법
Chlorocresol is prepared by the chlorination of m-cresol.
일반 설명
A pinkish to white crystalline solid with a phenolic odor. Melting point 64-66°C. Shipped as a solid or in a liquid carrier. Soluble in aqueous base. Toxic by ingestion, inhalation or skin absorption. Used as an external germicide. Used as a preservative in paints and inks.
공기와 물의 반응
Hygroscopic. Soluble in aqueous base.
반응 프로필
4-Chloro-3-methylphenolS are incompatible with bases, acid chlorides, acid anhydrides, and oxidizing agents. Corrodes steel, brass, copper and copper alloys .
위험도
Irritant to skin.
건강위험
Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
화재위험
Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Pharmaceutical Applications
Chlorocresol is used as an antimicrobial preservative in cosmetics and pharmaceutical formulations. It is generally used in concentrations up to 0.2% in a variety of preparations except those intended for oral administration or that contact mucous membrane. Chlorocresol is effective against bacteria, spores, molds, and yeasts; it is most active in acidic media. Preservative efficacy may be reduced in the presence of some other excipients, particularly nonionic surfactants.
색상 색인 번호
Chlorocresol is a biocide used for its disinfectant and preservative properties, in topicals or cutting fluid.
Safety Profile
Poison by intravenous, subcutaneous, and intraperitoneal routes. Moderately toxic by ingestion. An allergen. Mutation data reported. Incompatible with sodium hydroxide. When heated to decomposition it emits toxic fumes of Cl and phosgene. See also CRESOL and CHLOROPHENOLS.
잠재적 노출
Chlorinated phenol fungicide, microbiocide, and germicide used to control bacteria, yeasts, and fungi.
환경귀착
Biological. When p-chloro-m-cresol was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum, significant biodegradation with rapid adaptation was observed. At concentrations of 5 and 10 mg/L, 78 and 76% biodegradation, respectively, were observed after 7 d (Tabak et al., 1981).
Chemical/Physical. At influent concentrations (pH 3.0) of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities were 122, 63, 32, and 17 mg/g, respectively. At pH 5.5 and pH 9.0 at influent concentrations of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities were 124, 85, 58, and 40 mg/g and 99, 38, 15, and 5.5 mg/g, respectively (Dobbs and Cohen, 1980).
저장
Chlorocresol is stable at room temperature but is volatile in steam. Aqueous solutions may be sterilized by autoclaving. On exposure to air and light, aqueous solutions may become yellow colored. Solutions in oil or glycerin may be sterilized by heating at 1608℃ for 1 hour. The bulk material should be stored in a well-closed container, protected from light, in a cool, dry place.
운송 방법
UN2669 Chlorocresols solution, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3437 Chlorocresols solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods
Crystallise the phenol from pet ether or *C6H6. [Beilstein 6 H 381, 6 I 187, 6 II 355, 6 III 1315, 6 IV 2064.]
비 호환성
Chlorocresols react with boranes, alkalies, aliphatic amines, amides, nitric acid, sulfuric acid. Contact with oxidizing agents may cause a fire and explosion hazard. Heat produces phosgene, hydrogen chloride and chlorine gases. Corrosive to aluminum, copper, tin, and other chemically active metals.
폐기물 처리
A good candidate for rotary kiln incineration at a temperature range of 820 to 1600C and residence times of seconds for liquids and gases, and hours for solids.
Regulatory Status
Included in the FDA Inactive Ingredients Database (topical creams and emulsions). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
In Europe, chlorocresol is approved for use in cosmetics at a maximum concentration of 0.2%; however, it is prohibited for use in products intended to come into contact with mucous membranes. In Japan, use of chlorocresol in cosmetics is restricted to a level of 0.5 g/100 g.

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