RHOEADINE

RHOEADINE 화학적 특성, 용도, 생산

• 개요

  This alkaloid was found by Hesse in Papaver rhoeas Linn (red poppy) and its reputed existence in opium now appears doubtful. The base crystallizes from a mixture of CHCl3 and Et20 and sublimes at 21 5-225°C/0.02 mm. It has [α]^17.5_D + 232° (CHCI 3) or [α]¹⁹_D + 243° (CHCl3). It behaves as a weak base and is sparingly soluble in H20, alkaline solutions and most organic solvents. It dissolves in mineral acids giving an intensely red solution but investigation shows that only a small proportion of the alkaloid is used to produce the colour, the major part being converted into a colourless, crystalline substance, Rhoeagenine, a much stronger base, non-volatile, and stable to acids. This base is not isomeric with the alkaloid as first thought but has the formula C2oH1906N, m.p. 236-8°C; [α]¹⁹_D + l68° (AcOH).).
  Rhoeadine itself contains two methylenedioxy groups, one methoxy group and an N-methyl group. The salts are not easy to prepare but a crystalline hydriodide dihydrate is formed by addition of KI to a solution of the alkaloid in AcOH. The ultraviolet spectrum of the alkaloid shows absorption maxima at 205, 240 and 292 mμ.

• 용도

  As an isoquinoline alkaloid, Rhoeadine can be used in the therapeutic field particularly for the prevention and the treatment of pathologies implying a central and/or peripheral disorder.

• 참고 문헌

  Hesse., Annalen, Suppl., 4, 50 (1S65)
  Hesse., ibid, 140, 145 (1S66)
  Spath., Monatsh., 68,33 (1936)
  Awe., Arch. Pharm., 279,116 (1941)
  Santavy etat., Collect. Czech. Chem. Commun., 30,335,3479 (1965)
  Mass spectrum:
  Dolejs, Hanus., Tetrahedron, 23, 2997 (1967)
  Stereochemistry:
  Shamma et at., Chem. Commun., 212 (1968)

RHOEADINE 공급 업체

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